Neurodevelopmental consequences of being born SGA.
Neurodevelopmental consequences of being born SGA.
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出生 SGA 的神经发育后果。
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
A. van Wassenaer
中科院分区：
文献类型：
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作者：
A. van Wassenaer
胎儿生长迟缓与出生后生长迟缓和以后生活中的心血管和代谢问题有关。较少被描述的是神经发育结果的后果。与阿加对照组相比，长期SGA与轻度至中度的学校问题有关，在青春期后期仍然存在，并且在年轻的成年期具有较低的心理和智力表现。此外，早产SGA出生后，神经发育后遗症比早产阿加出生后更复杂。最近的体积MRI研究表明，大脑皮质灰质体积减少是胎儿生长迟缓的最重要特征之一。此外，海马似乎特别容易受到胎盘功能不全的影响。虽然生长激素治疗SGA出生后身材矮小的儿童已被证明可以增加头围，但迄今为止，生长激素治疗后没有临床显着的心理改善。
Fetal growth retardation is associated with postnatal growth retardation and cardio-vascular and metabolic problems later on in life. Less well described are the consequences of neurodevelopmental outcome. The term SGA is associated with mild to moderate school problems, still present in late puberty and with lower psychological and intellectual performance in young adulthood as compared with AGA controls. Also after preterm SGA birth, neurodevelopmental sequelae are more complex than after preterm AGA birth. Recent volumetric MRI studies of the brain show reduced cortical grey matter volume as one of the most important features of fetal growth retardation. In addition, the hippocampus appears to be especially susceptible to the effects of placental insufficiency. Although growth hormone treatment of children with short stature after SGA birth has been shown to increase head circumference, no clinically significant psychological improvement has been demonstrated after growth hormone treatment to date.