Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria
Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria
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DOI：
10.1016/j.jep.2005.04.038
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发表时间：
2005-10-03
影响因子：
5.4
通讯作者：
Gritsanapan, W
中科院分区：
文献类型：
--
作者：
Chomnawang, MT;Surassmo, S;Gritsanapan, W
痤疮丙酸杆菌和表皮葡萄球菌被认为是引发痤疮炎症的脓形成细菌。本研究旨在评估泰国药用植物对寻常痤疮病原体的抗菌活性。采用纸片扩散法和肉汤稀释法对粗提物进行抗菌活性测试。用纸片扩散法测定了13种药用植物对痤疮丙酸杆菌的抑制作用。其中，花番泻叶、飞机草、山竹根和蛇麻藤具有较强的抑制作用。基于肉汤稀释法，山竹提取物具有最大的抗菌效果。两种细菌的MIC值相同（0.039 mg/ml），对痤疮丙酸杆菌和表皮葡萄球菌的MBC值分别为0.039和0.156 mg/ml。在生物自显影试验中，山竹提取物对痤疮丙酸杆菌有较强的抑制作用。柱层析结果表明，山竹中的抑菌活性成分之一可能是山竹子素（mangostin），一种氧杂蒽酮衍生物。结果表明，山竹对痤疮丙酸杆菌和表皮葡萄球菌有较强的抑制作用。因此，这种植物将是进一步研究的一个有趣的话题，并可能成为痤疮的替代治疗方法。(C)2005爱思唯尔爱尔兰有限公司保留所有权利。
Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. The present study was conducted to evaluate antimicrobial activities of Thai medicinal plants against these etiologic agents of acne vulgaris. Crude extracts were tested for antimicrobial activities by disc diffusion and broth dilution methods. The results from the disc diffusion method showed that 13 medicinal plants could inhibit the growth of Propionibacterium acnes. Among those, Senna alata, Eupatorium odoratum, Garcinia mangostana, and Barleria lupulina had strong inhibitory effects. Based on a broth dilution method, the Garcinia mangostana extract had the greatest antimicrobial effect. The MIC values were the same (0.039 mg/ml) for both bacterial species and the MBC values were 0.039 and 0.156 mg/ml against Propionibacterium acnes and Staphylococcus epidermidis, respectively. In bioautography assay, the Garcinia mangostana extract produced strong inhibition zones against Propionibacterium acnes. Antimicrobial activity from fractions of column chromatography revealed one of the active compounds in Garcinia mangostana could be mangostin, a xanthone derivative. Taken together, our data indicated that Garcinia mangostana had a strong inhibitory effect on Propionibacterium acnes and Staphylococcus epidermidis. Therefore, this plant would be an interesting topic for further study and possibly for an alternative treatment for acne. (C) 2005 Elsevier Ireland Ltd. All rights reserved.