Immunohistologic patterns of congenital nevocellular nevi.
Immunohistologic patterns of congenital nevocellular nevi.
复制标题
先天性痣细胞痣的免疫组织学模式。
作者：
B. Nickoloff;R. Walton;K. Pregerson;A. Jacobs;A. Cox
为了建立敏感的先天性小痣（SCN）的组织学标准，我们检查了29例年龄小于1岁的SCN患者的活检标本，通过连续切片和S100免疫过氧化物酶染色。乳头状和网状真皮浸润的深度是可变的，只有6个活检标本的结果含有痣黑素细胞在网状真皮的下三分之一。然而，所有的病例都有局灶性的痣黑素细胞累及真皮中间网状层或以下的附件（29例中26例位于外分泌结构，29例中15例位于毛囊皮脂腺结构）。在10例患者的随访标本（平均间隔，10.25年），并没有观察到差异的组织学模式或细胞学。SCN的表面积有不同的大小增加，从没有增加到最大增加九倍。
To establish sensitive histologic criteria for small congenital nevi (SCN), we examined 29 biopsy specimens of SCN from patients younger than age 1 year by serial sectioning and S100 immunoperoxidase staining. The depth of papillary and reticular dermal infiltration was variable; only the results of six biopsy specimens contained nevomelanocytes in the lower third of reticular dermis. However, all cases had focal nevomelanocytic involvement of adnexa at the midreticular dermis or below (26 of 29 cases in eccrine and 15 of 29 in pilosebaceous structures). Follow-up specimens in ten patients were obtained (mean interval, 10.25 years), and no difference in histologic pattern or cytology was observed. There were variable size increases in the surface area of SCN, ranging from no increase to a maximal ninefold increase.
影响因子：
3.3
作者：
CLARK, WH;ELDER, DE;VANHORN, M
通讯作者：
VANHORN, M