Stanford's Outcomes Research in Kids (STORK): a prospective study of healthy pregnant women and their babies in Northern California
Stanford's Outcomes Research in Kids (STORK): a prospective study of healthy pregnant women and their babies in Northern California
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DOI：
10.1136/bmjopen-2015-010810
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发表时间：
2016-01-01
期刊：
影响因子：
2.9
通讯作者：
Parsonnet, Julie
中科院分区：
文献类型：
--
作者：
Ley, Catherine;Sanchez, Maria de la Luz;Parsonnet, Julie
目的：斯坦福大学儿童成果研究 (STORK) 是一个持续进行的健康孕妇及其婴儿的前瞻性队列，旨在确定传染病对儿童时期体重、线性生长和免疫系统发育的影响。此外，对家庭和个人清洁产品进行嵌套随机干预，测试了杀菌剂三氯生和三氯卡班对这些结果和感染发生率的影响。 参与者：健康孕妇主要在公共诊所进行识别和登记；他们的婴儿在出生后不久就被纳入研究，并被跟踪至 36 个月大。自动每周调查评估怀孕期间母亲和出生后婴儿的日常健康状况、传染病症状、医疗保健提供者就诊和抗生素使用情况。每 4 个月进行一次家访，从母亲（尿液、粪便、唾液、皮肤拭子）、婴儿（脚跟/脚趾采血、尿液、粪便、唾液、皮肤拭子）和家庭（环境拭子）收集信息和样本。每年通过静脉穿刺（母亲和婴儿）获取血样。提取了母亲在怀孕期间和婴儿的过敏和传染病的医学图表。 迄今为止的调查结果：从 7/2011 到 2/2015，158 名母亲在大约妊娠 20 周时入组； 127 名婴儿被登记。三分之二的母亲是西班牙裔，三分之一不是在美国出生，三分之一主要讲西班牙语；平均受教育年限为 13 (SD 6.2) 年。家庭平均有 4.5 名居民。大多数家庭（97%）被随机分配参与干预。在这个年轻的流动人口中，每周调查（86%）和随访（14 个月后 75%）的完成情况非常好；样本收集工作正在进行中，并已存储数千个样本。未来计划：将对登记的婴儿进行跟踪直至 36 个月大（最后一次预计就诊：07/2018），并在此后不久完成医疗图表审查。所有流行病学信息和样本都将可用于协作假设检验。
Purpose: Stanford's Outcomes Research in Kids (STORK) is an ongoing prospective cohort of healthy pregnant women and their babies established to determine the effect of infectious diseases on weight, linear growth and immune system development during childhood. Additionally, a nested randomised intervention of household and personal cleaning products tests the effects of the microbicides triclosan and triclocarban on these outcomes and incidence of infection.Participants: Healthy pregnant women were identified and enrolled primarily at public clinics; their babies, enrolled shortly after birth, are followed to age 36 months. Automated weekly surveys assess daily health status, infectious disease symptoms, healthcare provider visits and antibiotic use, in the mother during pregnancy and the baby once born. At 4-monthly household visits, information and samples are collected from the mother (urine, stool, saliva, skin swab), the baby (blood by heel/toe stick, urine, stool, saliva, skin swab) and the household (environmental swabs). Annual blood samples are obtained by venipuncture (mother and baby). Medical charts are abstracted for allergy and infectious illness in the mother during pregnancy and the baby.Findings to date: From 7/2011 to 2/2015, 158 mothers were enrolled at approximately 20 weeks gestation; 127 babies were enrolled. Two-thirds of mothers are Hispanic, one-third are non-US born and one-third speak primarily Spanish; mean years of education is 13 (SD 6.2) years. Households have on average 4.5 residents. Most households (97%) were randomised to participate in the intervention. Completion of weekly surveys (86%) and follow-up (75% after 14 months) is excellent in this young, mobile population; collection of samples is ongoing with thousands of specimens stored.Future plans: Enrolled babies will be followed until age 36 months (last anticipated visit: 07/2018) with medical chart review completed soon thereafter. All epidemiological information and samples will be available for collaborative hypothesis testing.