Tripartilactam, a Cyclobutane-Bearing Tricyclic Lactam from a Streptomyces sp in a Dung Beetle's Brood Ball
Tripartilactam, a Cyclobutane-Bearing Tricyclic Lactam from a Streptomyces sp in a Dung Beetle's Brood Ball
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DOI：
10.1021/ol300108z
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发表时间：
2012-03-02
期刊：
影响因子：
5.2
通讯作者：
Oh, Dong-Chan
中科院分区：
文献类型：
--
作者：
Park, Seon-Hui;Moon, Kyuho;Oh, Dong-Chan
三聚内酰胺是从链霉菌中发现的一种结构上前所未有的含环丁烷的三环内酰胺代谢产物。从粪甲虫的一个孵化球中分离出来的三色金龟子。通过核磁共振、质谱学、紫外光谱、红外光谱和多步化学衍生化相结合的方法确定了化合物的结构。三聚内酰胺是一种Na+/K+ATPase抑制剂(IC50=16.6µg/mL)。
Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na+/K+ ATPase inhibitor (IC50 = 16.6 mu g/mL).