TNF-α and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents
TNF-α and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents
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DOI：
10.2174/156720207779940716
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发表时间：
2007-02-01
影响因子：
2.1
通讯作者：
Bakhiet, Moiz
中科院分区：
文献类型：
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作者：
Al-Bahrani, Ali;Taha, Safa;Bakhiet, Moiz
卒中与几种促炎细胞因子的升高有关，如肿瘤坏死因子α(TNF-α)和白细胞介素8(IL-8)，它们与中枢神经系统(CNS)损伤有关。抗血小板治疗是卒中治疗中的重要药物。在急性中风患者中，抗血小板作为抗炎剂的作用尚不清楚。此外，它们在这些患者体内诱导潜在细胞因子如肿瘤坏死因子-α和白介素8的作用仍不清楚。因此。在此，我们检测了急性卒中患者肿瘤坏死因子-α和白介素8的诱导，并检测了抗血小板药物阿司匹林、氯吡格雷、双嘧达莫和吡拉西坦对其诱导的影响。用免疫细胞化学方法检测了首次急性缺血性卒中患者和匹配对照组的白细胞内细胞因子。结果显示，患者自发产生的肿瘤坏死因子-α和白介素8较对照组显著增加。每种药物和双重药物对这种诱导的抑制作用是不同的。本研究结果提示，抗血小板药物可能具有抑制卒中前炎症细胞因子作用的作用，这可能为抗血小板在急性缺血性卒中治疗中的作用开辟了一个新的方面。
Stroke is associated with elevation of several proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-8 that are correlated with central nervous system (CNS) injury. Anti-platelet therapies are important agents in stroke management. The role of antiplatelets as anti-inflammatory agents is not known in acute stroke patients. Furthermore, their effect on induction of potential cytokines as TNF-alpha and IL-8 in those patients is still not clear. Thus. we herein examined the induction of TNF-alpha and IL-8 in acute stroke patients and examined the effects of the antiplatelets drugs aspirin, clopidogrel and dipyridamole, and piracetam in their induction. Cytokines were detected intracellularly in leukocytes from patients who had first acute ischemic stroke and from matched controls by immunocytochemistry. The results showed significant increase of spontaneously produced TNF-alpha and IL-8 in patients compared to control. This induction was significantly inhibited differently by each drug and dual drug agents. The data of this work suggest that antiplatelets agents may have a role in inhibition of stroke mediated proinflammatory cytokine effects, which may initiate a new aspect of the role of antiplatelets in the treatment of acute ischemic stroke.