LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins.
LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins.
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DOI：
10.1006/jmbi.1999.2796
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发表时间：
1999-07-30
影响因子：
5.6
通讯作者：
Kim PS
中科院分区：
文献类型：
--
作者：
Singh M;Berger B;Kim PS
Crystallographic studies have shown that the coiled-coil motif occurs in several viral membrane-fusion proteins, including HIV-1 gp41 and influenza virus hemagglutinin. Here, the LearnCoil-VMF program was designed as a specialized program for identifying coiled-coil-like regions in viral membrane-fusion proteins. Based upon the use of LearnCoil-VMF, as well as other computational tools, we report detailed sequence analyses of coiled-coil-like regions in retrovirus, paramyxovirus and filovirus membrane-fusion proteins. Additionally, sequence analyses of these proteins outside their putative coiled-coil domains illustrate some structural differences between them. Complementing previous crystallographic studies, the coiled-coil-like regions detected by LearnCoil-VMF provide further evidence that the three-stranded coiled coil is a common motif found in many diverse viral membrane-fusion proteins. The abundance and structural conservation of this motif, even in the absence of sequence homology, suggests that it is critical for viral-cellular membrane fusion. The LearnCoil-VMF program is available at http://web.wi.mit.edu/kim
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DOI：
10.1089/cmb.1995.2.125
发表时间：
1995-01-01
期刊：
Journal of computational biology : a journal of computational molecular cell biology
影响因子：
--
作者：
Berger, B
通讯作者：
Berger, B
影响因子：
9.2
作者：
Fass, D;Kim, PS
通讯作者：
Kim, PS
影响因子：
64.5
作者：
CARR, CM;KIM, PS
通讯作者：
KIM, PS
DOI：
10.1073/pnas.95.26.15613
发表时间：
1998-12-22
影响因子：
11.1
作者：
Chan, DC;Chutkowski, CT;Kim, PS
通讯作者：
Kim, PS
影响因子：
56.9
作者：
HARBURY, PB;ZHANG, T;ALBER, T
通讯作者：
ALBER, T