Potential detection of cancer with fluorinated silicon nanoparticles in 19F MR and fluorescence imaging
Potential detection of cancer with fluorinated silicon nanoparticles in 19F MR and fluorescence imaging
复制标题
F-19 MR 和荧光成像中氟化硅纳米颗粒对癌症的潜在检测
DOI：
10.1039/c8tb00648b
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发表时间：
2018-07-14
影响因子：
7
通讯作者：
Zhou, Xin
中科院分区：
文献类型：
--
作者：
Li, Sha;Yuan, Yaping;Zhou, Xin
荧光由于其高灵敏度和丰富的颜色选择而被广泛用于细胞成像，但由于其低光穿透而用于体内成像。同时，磁共振成像（MRI）被广泛用于体内诊断，但由于其低分辨率而不适用于细胞成像。由于生物体中很少见的背景，F-19-MRI在临床应用的几个领域中脱颖而出。在此，我们报告了氟化硅纳米颗粒（（19）FSINPS）的一锅微波合成，用于检测癌细胞和肿瘤。基于纳米大小的纳米颗粒的量子效应，（19）FSINP可以充当无标记的无标记染料，用于超对抗细胞荧光成像。我们的实验表明，这些纳米探针显着增强了在具有非细胞细胞肺肿瘤大鼠的体内F-19/H-1 MRI对比度。此外，由此产生的（19）FSINP表现出高水的散发性和出色的生物相容性，这使它们对细胞成像和体内成像应用都有希望。
Fluorescence is widely used for cell imaging due to its high sensitivity and rich color choices but limited for in vivo imaging because of its low light penetration. Meanwhile, magnetic resonance imaging (MRI) is widely applied for in vivo diagnosis but not suitable for cell imaging because of its low resolution. As a result of rare background in living organisms, F-19-MRI stands out in several fields of clinical application. Herein, we report a one-pot microwave synthesis of fluorinated silicon nanoparticles ((19)FSiNPs), for detection of cancer cells and tumors. Based on the quantum effects of the nano-sized nanoparticles, (19)FSiNPs can act as a label free dye for ultracontrast cell fluorescence imaging. Our experiments demonstrated that these nanoprobes significantly enhanced in vivo F-19/H-1 MRI contrast in rats with nonsmall cell lung tumors. Moreover, the resulting (19)FSiNPs exhibited high water dispersibility and excellent biocompatibility, which make them promising for both cell imaging and in vivo imaging applications.