X-ray and crystallographic applications in pharmaceutical research. I. Trace element determinations by x-ray emission.
X-ray and crystallographic applications in pharmaceutical research. I. Trace element determinations by x-ray emission.
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X 射线和晶体学在药物研究中的应用。
DOI：
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发表时间：
1962
期刊：
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通讯作者：
J. W. Shell
中科院分区：
文献类型：
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作者：
J. W. Shell
本文以一种改进的类固醇中硒的测定方法为例，介绍了一种在常规基础上普遍适用于固体有机基质中任何重元素测定的标准程序。通用方法适用于高浓度和低浓度，如图所示，包括痕量。由于初级辐射的干扰，一般应用的例外情况是汞，并且描述了该元素的替代程序。通过铬和锰的测定程序，说明了将该方法扩展到较轻元素，并对这两种元素的替代方法进行了关键的比较。文中还对常见误差进行了统计研究，指出了较轻元素的最佳条件。
A standard procedure generally applicable on a routine basis to the determination of any heavy element in a solid organic matrix is described, using an improved method for the determination of selenium in steroids as an example. The general method is applicable for both high and low concentrations including, as is illustrated, trace quantities. An exception to the general application occurs with mercury, due to interferences from primary radiation, and an alternate procedure is described for this element. Extension of the method to lighter elements is illustrated by procedures for the determination of chromium and manganese, and a critical comparison of alternate procedures for these two elements is made. A statistical study of common errors showing optimum conditions for lighter elements is also presented.