Prognostic value of DNA ploidy: 5-year follow-up of patients with resectable squamous cell carcinoma (SCC) of the lung
Prognostic value of DNA ploidy: 5-year follow-up of patients with resectable squamous cell carcinoma (SCC) of the lung
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DOI：
10.1016/j.lungcan.2005.10.014
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发表时间：
2006-02-01
期刊：
影响因子：
5.3
通讯作者：
Kaczmarek, E
中科院分区：
文献类型：
--
作者：
Kasprzyk, M;Dyszkiewicz, W;Kaczmarek, E
本研究旨在揭示可切除肺癌患者dna倍性与其5年生存率之间的关系。这些结果与我们在2000年发表的对同一组患者的2年随访研究结果进行了比较。我们对1995年至1996年间接受肺切除术的80例SCC患者进行了重新分析。统计分析采用Cox风险模型和expotential多元回归模型。采用Kaptan-Meier法绘制生存曲线。在45%的癌症肿瘤中发现dna非整倍体。非整倍体与性别、年龄、癌症分期或分级无统计学意义相关。在3年的随访中，非整倍体肿瘤患者的生存率明显低于二倍体肿瘤患者。然而，在5年的随访后，没有发现这种差异。肿瘤倍体仅在55 - 60岁的患者中是一个独立的预后因素。非整倍体肿瘤患者的死亡率主要是远处转移，而二倍体肿瘤患者的死亡率主要是局部复发。在手术切除后的前三年，非整倍体肿瘤患者远端转移的风险高于二倍体肿瘤患者。肿瘤倍体可以被认为是年轻（55-60岁）患者的独立预后因素。非整倍体促进早期远处转移的发生，而二倍体类型与晚期（3年后）局部肿瘤复发相关。2005爱思唯尔爱尔兰有限公司版权所有。
This study was designed to show the relation between DNA-ploidy in patients with resectable lung cancers and their 5-year survival rate. The results are compared with those from our 2-year follow-up study of the same group of patients published in 2000.The group of 80 patients with SCC who underwent lung resection between 1995 and 96 were re-analyzed. For the statistical analysis the hazard Cox model and an expotential multiple regression model were used. The survival curves were drawn using the Kaptan-Meier method.DNA-aneuploidy was found in 45% of cancer tumors. There was no statistically significant correlation between aneuploidy and gender, age, cancer staging or grading. In the 3-year follow-up the survival rate in patients with aneuploid type tumors was significantly lower than in those with the diploid type. However, this difference was not found after 5 years of follow-up. Tumor ploidy was an independent prognostic factor only in patients between 55 and 60 years of age. The mortality rate in patients with aneuploid tumors was mainly the result of distant metastases while, in patients with diploid tumors, local recurrence was the main reason for death.In the first three years after surgical resection patients with aneuploid tumors are at higher risk of distant metastases than patients with the diploid type.Tumor ploidy can be recognized as an independent prognostic factor in younger (55-60) patients.Aneuploidy promoted the occurrence of early distant metastases white the diploid type was associated with late (after 3 years) local tumor recurrence. (c) 2005 Elsevier Ireland Ltd. All rights reserved.