Validation of a New Retinopathy of Prematurity Screening Method Monitoring Longitudinal Postnatal Weight and Insulinlike Growth Factor I
Validation of a New Retinopathy of Prematurity Screening Method Monitoring Longitudinal Postnatal Weight and Insulinlike Growth Factor I
复制标题
DOI：
10.1001/archophthalmol.2009.69
复制
发表时间：
2009-05-01
影响因子：
--
通讯作者：
Hellstrom, Ann
中科院分区：
文献类型：
--
作者：
Loqvist, Chatarina;Hansen-Pupp, Ingrid;Hellstrom, Ann
目标：为了验证在前瞻性研究中的监测算法WINROP检测早产儿增殖性视网膜病变（ROP）的风险。方法：50名早产儿，平均胎龄为26周。在WINROP的第一步，每周测量体重和血清胰岛素样生长因子I（IGF-I）水平，从出生到月经后年龄36周，并与预期的发展进行比较。如果任何变量显示出一定程度的负偏差，则发出警报。在第二步中，孕龄，出生体重，和IGF结合蛋白3 levelwerentered.Results：WINROP算法确定了所有儿童（100%的灵敏度）谁被诊断为增殖性ROP 1.1至21.6周后。无警报或警报低风险的婴儿均未发生增殖性ROP。报警在月经后32周的年龄之前的高风险给予22的50名婴儿（44%），这些婴儿中的9人发展增殖性ROP（54%的特异性），其中8人treated.Conclusion：WINROP算法可能是一个有用的工具，修改ROP筛查。
Objective: To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP).Methods: Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered.Results: The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with proliferative ROP 1.1 to 21.6 weeks later. No infants with no alarm or with alarm at low risk developed proliferative ROP. Alarm at high risk before postmenstrual age 32 weeks was given for 22 of 50 infants (44%); 9 of these infants developed proliferative ROP (54% specificity), of whom 8 were treated.Conclusion: The WINROP algorithm may be a useful tool for modification of ROP screening.