Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1.
Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1.
复制标题
DOI：
10.1128/microbiolspec.bai-0024-2019
复制
发表时间：
2019-05
影响因子：
3.7
通讯作者：
S. Tiwari;R. Casey;C. Goulding;Suzie Hingley‐Wilson;W. Jacobs
中科院分区：
文献类型：
--
作者：
S. Tiwari;R. Casey;C. Goulding;Suzie Hingley‐Wilson;W. Jacobs
结核分枝杆菌是引起人类疾病的古老艺术大师。在其全副武装的武器库中，一个重要的武器是VII型分泌系统。结核分枝杆菌有5个：ESAT-6分泌系统（ESX） 1至5。长期以来，ESX-1一直被认为是fda许可的牛分枝杆菌卡介苗疫苗衰减的主要原因，但其在疾病进展和传播中的重要性最近得到了更详细的阐明。本文综述了以下方面的最新进展：(i)对ESX-1结构和成分的理解，（ii）我们对ESX-1在劫持巨噬细胞功能以设置感染和传播途径中的作用的了解，以及（iii）利用ESX-1进行诊断、药物干预、宿主定向治疗和疫苗的干预措施的发展。
ABSTRACT Mycobacterium tuberculosis is an ancient master of the art of causing human disease. One important weapon within its fully loaded arsenal is the type VII secretion system. M. tuberculosis has five of them: ESAT-6 secretion systems (ESX) 1 to 5. ESX-1 has long been recognized as a major cause of attenuation of the FDA-licensed vaccine Mycobacterium bovis BCG, but its importance in disease progression and transmission has recently been elucidated in more detail. This review summarizes the recent advances in (i) the understanding of the ESX-1 structure and components, (ii) our knowledge of ESX-1’s role in hijacking macrophage function to set a path for infection and dissemination, and (iii) the development of interventions that utilize ESX-1 for diagnosis, drug interventions, host-directed therapies, and vaccines.