The ageing immune system: is it ever too old to become young again?
The ageing immune system: is it ever too old to become young again?
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DOI：
10.1038/nri2471
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发表时间：
2009-01-01
影响因子：
100.3
通讯作者：
Signer, Robert A. J.
中科院分区：
文献类型：
--
作者：
Dorshkind, Kenneth;Montecino-Rodriguez, Encarnacion;Signer, Robert A. J.
衰老伴随着免疫系统功能的下降，这增加了对感染的易感性，并可能降低生活质量。因此，使衰老的免疫系统恢复活力的能力将有利于老年人，并将降低社会的医疗保健成本。但是，免疫系统是否会因为太老而无法再次变得年轻？我们在这里回顾了各种方法的承诺，以振兴免疫系统的功能，在迅速增长的老龄化人口。
Ageing is accompanied by a decline in the function of the immune system, which increases susceptibility to infections and can decrease the quality of life. The ability to rejuvenate the ageing immune system would therefore be beneficial for elderly individuals and would decrease health-care costs for society. But is the immune system ever too old to become young again? We review here the promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population.