Siglecs as positive and negative regulators of the immune system
Siglecs as positive and negative regulators of the immune system
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DOI：
10.1042/bst0361467
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发表时间：
2008-12-01
影响因子：
3.9
通讯作者：
Redelinghuys, Pierre
中科院分区：
文献类型：
--
作者：
Crocker, Paul R.;Redelinghuys, Pierre
Siglecs（唾液酸结合lg样凝集素）主要在免疫系统中表达。Sn（sialoadhesin）（siglec-1）、CD 22（siglec-2）和siglec-15是非常保守的，而CD 33相关的siglec正在经历快速进化，这反映在迄今为止研究的不同哺乳动物之间的库的巨大差异中。在本文中，我们回顾了最近的研究结果的CD 33相关的单细胞的信号转导特性，并讨论了这个家庭的抑制和激活形式的出现。我们还讨论了如何锡可能作为一个积极的调节适应性免疫反应和其新兴的作用，作为诱导的巨噬细胞模式识别分子唾液酸化的病原体，特别是包膜病毒。
Siglecs (sialic acid-binding lg-like lectins) are mainly expressed in the immune system. Sn (sialoadhesin) (siglec-1), CD22 (siglec-2) and siglec-15 are well conserved, whereas the CD33-related siglecs are undergoing rapid evolution, as reflected in large differences in repertoires among the different mammals studied so far. In the present paper, we review recent findings on the signalling properties of the CD33-related siglecs and discuss the emergence of both inhibitory and activating forms of this family. We also discuss how Sn may function as a positive regulator of adaptive immune responses and its emerging role as an induced macrophage pattern-recognition molecule for sialylated pathogens, especially enveloped viruses.