A case-control study of parental occupation, leukemia, and brain tumors in an industrial city in Taiwan
A case-control study of parental occupation, leukemia, and brain tumors in an industrial city in Taiwan
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DOI：
10.1097/01.jom.0000138913.75380.13
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发表时间：
2004-09-01
影响因子：
3.2
通讯作者：
Christiani，DC
中科院分区：
文献类型：
--
作者：
Ali，R;Yu，CL;Christiani，DC
我们在台湾的一个工业城市进行了一项病例对照研究，以确定新诊断的30岁以下白血病或脑瘤患者的父母或患者本身是否更有可能从事某些职业或行业。研究人员收集了103例新诊断的白血病病例、74例新诊断的脑肿瘤病例和417例年龄和性别匹配的对照组的父母（以及工作的受试者）的工作经历。所有的工作，从16岁的受试者举行了超过6个月，共约4000个工作，职业和行业的编码，根据标准的四位数系统在台湾使用。配对分析进行比较的情况下，控制对象和父母双方使用四位数的职业和行业代码举行的所有工作。单独的分析也进行了在孕前，围产期和产后期间举行的父母的工作。根据受试者吸烟、父母吸烟和医疗辐射暴露调整比值比（OR）。某些行业和职业的四位数编码与儿童肿瘤的优势比增加显著相关。包括在任何或所有时期的工作，白血病更常见于父亲曾从事木材加工的儿童（调整OR 16.03，95%可信区间CI= 1.77-145.5），（2）作为建筑装修工和相关行业工人（调整OR 4.08，95%CI = 1.12-14.8），而脑肿瘤在母亲曾在电子零部件制造业工作的儿童中更常见（1）（2）纺织服装工人（调整后OR为7.25，95%CI为1.42-37.0），以及从事电子元器件工作者（调整后OR为28.67，95%CI为2.88-285.6）。在受孕前，父亲从事木工工作的孩子更容易患白血病（调整后OR 12.17，95%CI = 1.36-109.2），（2）作为建筑装修工人和相关行业工人（调整OR 4.08，95%CI = 1.12-14.8），（3）电子设备装配工（调整后OR 4.56，95%CI = 11.05 -19.9），以及（4）某些其他组装者（调整后OR 10.24，95%CI = 1.02-102.6）。此外，在围产期父亲曾从事木工（调整后OR 13.08，95%CI = 1.36-125.5）和建筑装修工及相关行业工人（调整后OR 4.51，95%CI = 1.04-19.6）的儿童中白血病更常见。母亲在孕前时期从事电子零部件制造业（调整后OR 11.81，95%CI = 1.20-116.3）和纺织服装工人（调整后OR 7.25，95%CI = 1.18-31.0）的儿童更常见脑肿瘤。
We conducted a case-control study in an industrial city in Taiwan to determine whether parents of newly diagnosed patients who were younger than 30 years old with leukemia or brain tumors or the patients themselves were more likely to have been employed in certain occupations or industries. Job histories were collected for parents (and for subjects if they worked) on 103 newly diagnosed cases of leukemia, 74 newly diagnosed cases of brain tumors, and 417 controls matched for age and sex. All jobs since the age of 16 that the subjects held for more than 6 months, a total of approximately 4000 jobs, were coded for occupation and industry according the standard four-digit system used in Taiwan. Matched-pair analyses were performed comparing cases and controls among all jobs held by subjects and both parents using four-digit occupation and industry codes. Separate analyses also were performed for parental jobs held during the preconception, perinatal, and postnatal periods. Odds ratios (ORs) were adjusted for subject smoking, parental smoking, and exposure to medical radiation. Certain industry and occupation four-digit codes were significantly associated with increased odds ratios of childhood tumors. Including work during any or all periods, leukemias were more common in children of fathers who had worked (1) as wood treaters (adjusted OR 16.03, 95% confidence interval CI= 1.77–145.5), and (2) as building finishers and related trades workers (adjusted OR 4.08, 95% CI= 1.12–14.8), whereas brain tumors were more common in children of mothers who had worked (1) in electronic parts and components manufacturing (adjusted OR 13.78, 95% CI= 1.47–129.0) and 2) as textile and garment workers (adjusted OR 7.25, 95% CI= 1.42–37.0), as well as in subjects who had worked with certain electronic parts and components (adjusted OR 28.67, 95% CI= 2.88–285.6). Leukemias were more common in children of fathers who had worked in the preconception period (1) as wood treaters (adjusted OR 12.17, 95% CI= 1.36–109.2),(2) as building finishers and related trades workers (adjusted OR 4.08, 95% CI= 1.12–14.8),(3) as electronic equipment assemblers (adjusted OR 4.56, 95% CI= I 1.05–19.9), and (4) as certain other assemblers (adjusted OR 10.24, 95% CI= 1.02–102.6). In addition, leukemias were more common in children of fathers who had worked in the perinatal period (1) as wood treaters (adjusted OR 13.08, 95% CI= 1.36–125.5) and (2) as building finishers and related trades workers (adjusted OR 4.51, 95% CI= 1.04–19.6). Brain tumors were more common in children of mothers who had worked in the preconception period (1) in electronic parts and components manufacturing (adjusted OR 11.81, 95% CI= 1.20–116.3), and (2) as textile and garment workers (adjusted OR 7.25, 95% CI= 1.18–31.0).