Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain
Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain
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DOI：
10.3389/fnana.2019.00021
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发表时间：
2019-02-21
影响因子：
2.9
通讯作者：
Munoz-Lopez, Monica
中科院分区：
文献类型：
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作者：
Insausti, Ricardo;Corcoles-Parada, Marta;Munoz-Lopez, Monica
环回是内侧颞叶（MTL）的一个大体解剖学上的突出，与Brodmann 34区（BA 34）密切相关。它主要由内嗅皮层（EC）的内侧中间亚区[Brodmann 28区（BA 28）]形成。虽然MTL因其在记忆和空间信息中的作用而被广泛研究，但G。尚未完全定义BA 34和内侧中间EC亚区，特别是BA 34是EC的一部分还是不同类型的皮质。为了阐明这一问题，我们对37例人类MTL进行了详细的分析，确定了内侧中间EC亚区的确切位置及其在G.环膜、皮质厚度以及G.在10个离体MRI中，环肌与内侧中间EC子场。结果表明，G.环神经仅限于MTL内侧的两个小沟之间，这几乎完全对应于内侧中间EC亚区的范围，尽管G.环膜可以延伸到嗅觉（吻侧）和中间（尾侧）内嗅子区。此外，皮质厚度平均为2.5 mm（I-III层为1.3 mm，V-VI层为1 mm）。此外，在MRI扫描中可见的与G.提供了MRI中的环境。这些结果表明，BA 34是EC的一部分，最适合与内侧中间子场。组织学数据以及这些结构的离体MRI识别和厚度可用于评估临床环境中MRI扫描的变化，例如阿尔茨海默病。
The Gyrus ambiens is a gross anatomical prominence in the medial temporal lobe (MTL), associated closely with Brodmann area 34 (BA34). It is formed largely by the medial intermediate subfield of the entorhinal cortex (EC) [Brodmann area 28 (BA28)]. Although the MTL has been widely studied due to its well-known role on memory and spatial information, the anatomical relationship between G. ambiens, BA34, and medial intermediate EC subfield has not been completely defined, in particular whether BA34 is part of the EC or a different type of cortex. In order to clarify this issue, we carried out a detailed analysis of 37 human MTLs, determining the exact location of medial intermediate EC subfield and its extent within the G. ambiens, its cortical thickness, and the histological-MRI correspondence of the G. ambiens with the medial intermediate EC subfield in 10 ex vivo MRI. Our results show that the G. ambiens is limited between two small sulci in the medial aspect of the MTL, which correspond almost perfectly to the extent of the medial intermediate EC subfield, although the rostral and caudal extensions of the G. ambiens may extend to the olfactory (rostrally) and intermediate (caudally) entorhinal subfields. Moreover, the cortical thickness averaged 2.5 mm (1.3 mm for layers I-III and 1 mm for layers V-VI). Moreover, distance among different landmarks visible in the MRI scans which are relevant to the identification of the G. ambiens in MRI are provided. These results suggest that BA34 is a part of the EC that fits best with the medial intermediate subfield. The histological data, together with the ex vivo MRI identification and thickness of these structures may be of use when assessing changes in MRI scans in clinical settings, such as Alzheimer disease.