Reorganization of auditory cortex in tinnitus
Reorganization of auditory cortex in tinnitus
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DOI：
10.1073/pnas.95.17.10340
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发表时间：
1998-08-18
影响因子：
11.1
通讯作者：
Flor, H
中科院分区：
文献类型：
--
作者：
Mühlnickel, W;Elbert, T;Flor, H
采用磁源成像技术研究耳鸣患者的听觉皮层是否偏离了正常的功能组织。10名耳鸣受试者和15名健康对照者暴露于四组音调中，同时依次从两个皮层半球获得脑磁图记录。观察到耳鸣频率的皮质表征明显转移到与预期张力异位位置相邻的区域。耳鸣频率与声位图轨迹的欧氏距离为5.3 mm (SD = 3.1)，健康对照组相应频率的欧氏距离为2.5 mm (SD = 1.3) （t = 3.13, P < 0.01）。耳鸣主观强度与皮层重组量呈正相关（r = 0.82, P < 0.01）。这些结果表明耳鸣与听觉皮层的可塑性改变有关。这些数据与先前关于幻肢痛与皮层重组高度相关的研究结果相似，提示耳鸣可能是一种听觉幻肢现象。
Magnetic source imaging was used to determine whether tonotopy in auditory cortex of individuals with tinnitus diverges from normative functional organization. Ten tinnitus subjects and 15 healthy controls were exposed to four sets of tones while magnetoencephalographic recordings were obtained from the two cortical hemispheres in sequence. A marked shift of the cortical representation of the tinnitus frequency into an area adjacent to the expected tonotopic location was observed. The Euclidean distance of the tinnitus frequency from the trajectory of the tonotopic map was 5.3 mm (SD = 3.1) compared with a distance of 2.5 mm (SD = 1.3) of a corresponding frequency in the healthy controls (t = 3.13, P < 0.01). In addition, a strong positive correlation was found between the subjective strength of the tinnitus and the amount of cortical reorganization (r = 0.82, P < 0.01). These results demonstrate that tinnitus is related to plastic alterations in auditory cortex. Similarities between these data and the previous demonstrations that phantom limb pain is highly correlated with cortical reorganization suggest that tinnitus may be an auditory phantom phenomenon.