Infusing hope into the treatment of suicidality: A review of ketamine's effects on suicidality.
Infusing hope into the treatment of suicidality: A review of ketamine's effects on suicidality.
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为自杀治疗注入希望：氯胺酮对自杀影响的回顾。
DOI：
10.1007/s40473-019-00184-3
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发表时间：
2019
影响因子：
1.7
通讯作者：
Price,RebeccaB
中科院分区：
文献类型：
--
作者：
Rengasamy,Manivel;Hsiung,Kimberly;Price,RebeccaB
鉴于近期自杀率的上升和缺乏对自杀的快速治疗，氯胺酮已被确定为一种潜在的快速抗自杀治疗方法。鉴于有关氯胺酮用于降低自杀率的文献越来越多，我们的综述旨在描述氯胺酮对自杀率的影响。我们检查开放标签研究和随机对照试验评估氯胺酮治疗自杀。此外，我们的手稿确定了氯胺酮对自杀影响的潜在机制。根据现有的随机对照试验，氯胺酮似乎具有快速的抗自杀效果，大多数文献研究这种效果的时间范围不到一周。虽然仍处于研究的早期阶段，但氯胺酮的机制包括调节分子、炎症、神经、认知和行为过程。因此，氯胺酮似乎是一种很有希望的自杀治疗方法，但需要更大规模和更强大的随机对照试验来证实这种药物在临床环境中的潜在应用。
Purpose of ReviewGiven recent increases in rates of suicide and lack of rapid treatments for suicidality, ketamine has been identified as a potential fast-acting anti-suicidal treatment. Our review seeks to describe the effects of ketamine on suicidality, given the growing literature on the use of ketamine in reducing suicidality. We examine open-label studies and randomized controlled trials evaluating the treatment of suicidality with ketamine. Furthermore, our manuscript identifies potential mechanisms of ketamine’s effects on suicidality.Recent FindingsBased on existing RCTs, ketamine appears to have rapid anti-suicidal effects, with most literature studying such effects in timeframes less than 1 week. Although still in the early stages of research, mechanisms of ketamine include modulation of molecular, inflammatory, neural, cognitive, and behavioral processes.SummaryThus, ketamine appears to be a promising treatment for suicidality but requires larger scale and more robust RCTs to confirm the potential use of this agent in clinical settings.