Skeletal uptake of 99mTc-diphosphonate in relation to local bone blood flow.
Skeletal uptake of 99mTc-diphosphonate in relation to local bone blood flow.
复制标题
99mTc-二磷酸盐的骨骼摄取与局部骨血流量的关系。
作者：
B. Siegel;R. L. Donovan;P. Alderson;G. Mack
测定对照大鼠、右股动脉结扎大鼠和右胫骨骨折愈合大鼠胫骨左/右摄取99mtc -二膦酸盐（EHDP）的比例和相对血流量（基于微球分布）。相对血流量比小于1.7时，99mTc-EHDP摄取与相对血流量相关性极显著（r=0.917; P < 0.0001）。当比值大于1.7时，99mTc-EHDP的吸收几乎没有进一步增加。骨折愈合大鼠的股动脉结扎导致血流量比99mTc-EHDP摄取更明显的减少。这些结果表明，区域骨血流量是99mTc-EHDP摄取的主要决定因素，尽管区域示踪剂提取效率的变化也很重要。
The right/left ratios of tibial uptake of 99mTc-diphosphonate (EHDP) and relative blood flow (based on microsphere distribution) were determined in control rats and rats with a ligated right femoral artery or a healing right tibial fracture. Correlation between 99mTc-EHDP uptake and relative blood flow was highly significant (r=0.917; P less than 0.0001) for relative flow ratios less than 1.7. When the ratio was greater than 1.7, there was little further increase in 99mTc-EHDP uptake. Ligation of the femoral artery in rats with healing fractures resulted in a more marked reduction of blood flow than of 99mTc-EHDP uptake. These results suggest that regional bone blood flow is a major determinant of 99mTc-EHDP uptake, though changes in regional tracer extraction efficiency are also important.