Active force perception depends on cerebellar function
Active force perception depends on cerebellar function
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DOI：
10.1152/jn.00983.2011
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发表时间：
2012-03-01
影响因子：
2.5
通讯作者：
Bastian, Amy J.
中科院分区：
文献类型：
--
作者：
Bhanpuri, Nasir H.;Okamura, Allison M.;Bastian, Amy J.
Bhanpuri NH, Okamura AM, Bastian AJ。主动力知觉依赖于小脑功能。中国生物医学工程杂志[J] .中国生物医学工程杂志。首次发表于2011年12月21日；doi: 10.1152 / jn.00983.2011。-小脑损伤引起特征性运动异常，但被认为对体感知觉影响极小。小脑病变患者的传统临床评估显示，尽管小脑接收大量的体感信息，但没有知觉缺陷。鉴于预测运动视觉结果的异常已经被报道，我们怀疑小脑在需要运动输出时广泛参与感知（即主动感知）。因此，我们假设小脑的完整性对需要运动活动的体感知觉至关重要，而不是被动的体感知觉。我们比较了人类小脑患者在几种不同的体感知觉任务中与健康对照者的感知敏锐度。我们发现，患者在主动力和僵硬辨别方面较差，但在被动皮肤力检测、被动本体感觉检测和被动本体感觉辨别方面与对照组相似。此外，通过临床检查评估的运动症状的严重程度与主动力量感知的损害呈正相关。值得注意的是，在这些感知任务的背景下，对照组和小脑患者表现出相似的运动特征，因此不同的运动策略不太可能是感知差异的基础。我们的结果与小脑对自我产生运动的感觉预测至关重要的假设是一致的，并表明小脑在多种形式的主动感知中起着普遍的作用。
Bhanpuri NH, Okamura AM, Bastian AJ. Active force perception depends on cerebellar function. J Neurophysiol 107: 1612-1620, 2012. First published December 21, 2011; doi:10.1152/jn.00983.2011.-Damage to the cerebellum causes characteristic movement abnormalities but is thought to have minimal impact on somatosensory perception. Traditional clinical assessments of patients with cerebellar lesions reveal no perceptual deficits despite the fact that the cerebellum receives substantial somatosensory information. Given that abnormalities have been reported in predicting the visual consequences of movement, we suspect that the cerebellum broadly participates in perception when motor output is required (i.e., active perception). Thus we hypothesize that cerebellar integrity is essential for somatosensory perception that requires motor activity, but not passive somatosensory perception. We compared the perceptual acuity of human cerebellar patients to that of healthy control subjects in several different somatosensory perception tasks with minimal visual information. We found that patients were worse at active force and stiffness discrimination but similar to control subjects with regard to passive cutaneous force detection, passive proprioceptive detection, and passive proprioceptive discrimination. Furthermore, the severity of movement symptoms as assessed by a clinical exam was positively correlated with impairment of active force perception. Notably, within the context of these perceptual tasks, control subjects and cerebellar patients displayed similar movement characteristics, and hence differing movement strategies are unlikely to underlie the differences in perception. Our results are consistent with the hypothesis that the cerebellum is vital to sensory prediction of self-generated movement and suggest a general role for the cerebellum in multiple forms of active perception.