Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
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DOI：
10.1038/32190
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发表时间：
1998-03-05
期刊：
影响因子：
64.8
通讯作者：
Galli, SJ
中科院分区：
文献类型：
--
作者：
Lantz, CS;Boesiger, J;Galli, SJ
细胞因子白介素-3 （IL-3）可以从T细胞和其他来源获得，是免疫系统和造血系统之间潜在的重要联系(1)。IL-3可能对组织肥大细胞（1-6）和血液嗜碱性细胞（7,8）的发育、存活和功能特别重要，它们被认为是对寄生虫和其他免疫反应（如过敏反应）免疫的重要效应细胞(9)。在这里，我们使用IL-3缺陷小鼠（10）表明，在生理条件下，IL-3对肥大细胞或嗜碱性粒细胞的产生不是必需的，但它确实有助于增加组织肥大细胞的数量，增强嗜碱性粒细胞的产生，以及感染委内瑞拉强线虫的小鼠的免疫力。在IL-3缺陷小鼠中，寄生虫的排出和肥大细胞的发育受到更严重的损害，同时c-kit信号传导也显着减少。这些发现确定了IL-3在寄生虫免疫中的作用，并表明IL-3在宿主防御感染中的功能之一是扩大造血效应细胞的种群。
The cytokine interleukin-3 (IL-3), which can be derived from T cells and other sources, is a potentially important link between the immune and haematopoietic systems(1). IL-3 may be particularly critical for the development, survival and function of tissue mast cells(1-6) and blood basophils(7,8), which are thought to be important effector cells in immunity to parasites and other immunological responses, such as allergic reactions(9). Here we show using IL-3-deficient mice(10), that IL-3 is not essential for the generation of mast cells or basophils under physiological conditions, but that it does contribute to increased numbers of tissue mast cells, enhanced basophil production, and immunity in mice infected with the nematode Stronglyoides venezuelensis, Parasite expulsion and mast-cell development are impaired even more severely in IL-3-deficient mice that also show a marked reduction in signalling by c-kit, These findings establish a role for IL-3 in immunity to parasites and indicate that one of the functions of IL-3 in host defence against infection is to expand populations of haematopoietic effector cells.