Asymmetry in dopamine D2/3 receptors of caudate nucleus is lost with age
Asymmetry in dopamine D2/3 receptors of caudate nucleus is lost with age
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DOI：
10.1016/j.neuroimage.2006.10.013
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发表时间：
2007-02-01
期刊：
影响因子：
5.7
通讯作者：
Gruender, Gerhard
中科院分区：
文献类型：
--
作者：
Vernaleken, Ingo;Weibrich, Carsten;Gruender, Gerhard
分子和功能成像技术揭示了人类大脑功能偏侧化的证据。基于动物数据，我们假设多巴胺神经传递的不对称性在正常衰老过程中会下降。为了验证这一假说，我们用[18F]去甲氧基福尔马林PET(DMFP)测量了21名健康的右利手男性(24-60岁；35+/-10岁)的壳核和尾状核(NC)中多巴胺D2/3受体的可用性。对于容量分析，18名PET受试者获得了高分辨率的T1加权MR图像，以评估NC和壳核体积可能与年龄相关的减少。计算的DMFP结合电位(BP)显示，年轻受试者NC的右向不对称性随着年龄的增加而减少(r=0.577，p=0.006；皮尔逊相关；双尾)。年龄无关分析显示，整个受试组NC向右不对称(左：1.49+/-0.35；右：1.65+/-0.43[平均值+/-S.D.]；p=0.020)。在壳核中未发现这种副作用或年龄效应。壳核的体积趋于不对称(右：4.85+/-0.56 cm(3)；左：4.64+/-0.86 cm(3)[平均值+/-S.D.]；p=0.063)，但在NC中不是。随着年龄的增长，右侧壳核体积显著减少(r=-0.613；p=0.007；皮尔逊相关；双尾)。纹状体体积与年龄或血压之间没有其他显著的相关性。由于腹侧纹状体多巴胺神经传递参与认知过程，这种在衰老过程中失去生理不对称性的NC多巴胺传递可能与年龄相关的认知能力下降有关。(C)2006 Elsevier Inc.保留所有权利。
Molecular and functional imaging techniques reveal evidence for lateralization of human cerebral function. Based on animal data, we hypothesized that asymmetry in dopamine neurotransmission declines during normal aging. In order to test this hypothesis, we measured dopamine D2/3 receptor availability with [ 18F]desmethoxyfallypride-PET (DMFP) in putamen and caudate nucleus (NC) of 21 healthy, right-handed males (24-60 years; 35 +/- 10). For volumetric analysis, high-resolution T1-weighted MR-images were obtainedin 18 of the PET-subjects in order to assess possible age-related decreases in NC and putamen volume. The calculated DMFP binding potentials (BP) showed a right-ward asymmetry in NC of young subjects that decreased with age (r=0.577, p=0.006; Pearson correlation; two-tailed). An age-independent analysis showed a right-ward asymmetry in NC of the whole subject group (left: 1.49 +/- 0.35; right: 1.65 +/- 0.43 [mean +/- S.D.]; p=0.020). No such side lateralization or age-effects could be found in the putamen. Volumes tended to be asymmetric in the putamen (right: 4.85 +/- 0.56 cm(3); left: 4.64 +/- 0.86 cm(3) [mean +/- S.D.]; p=0.063), but not in NC. The decline of putamen volume during aging was significant in the right putamen (r=-0.613; p=0.007; Pearson correlation; two-tailed). There were no other significant correlations between striatal volumes and age or BP. Because ventral striatal dopamine neurotransmission is involved in cognitive processes, this loss of physiological asymmetry in NC dopamine transmission during aging might be involved in age-related declines of cognitive performance. (c) 2006 Elsevier Inc. All rights reserved.