Auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration: Short-term results
Auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration: Short-term results
复制标题
DOI：
10.1620/tjem.191.7
复制
发表时间：
2000-05-01
影响因子：
2.2
通讯作者：
Tamai, M
中科院分区：
文献类型：
--
作者：
Abe, T;Yoshida, M;Tamai, M
渗出型老年性黄斑变性患者的自体虹膜色素上皮细胞移植。7例AMD患者虹膜切除术后用自体血清进行自体IPE细胞培养。在去除新生血管膜后，细胞悬浮液(2个类似于20×10(4)细胞)仅移植到个体的黄斑下病变中。随后进行眼科检查，包括最佳矫正视力和荧光素或吲哚青绿血管造影。此外，15名AMD患者在没有移植的情况下接受了新生血管膜摘除，仅被评估为非随机对照。所有患者均可见不同程度的脉络膜毛细血管和视网膜色素上皮萎缩或缺失。治疗后未见黄斑囊样水肿或荧光素渗漏，仅有窗口缺陷。没有患者视力下降。一名接受治疗的患者发展为轻度视网膜下纤维化，另一名患者发展为轻度视网膜前纤维化，但与对照组相比没有显著差异。结论：与对照组相比，治疗组的黄斑功能没有明显改善，但在13个月的随访期内，没有发生排斥反应或视力下降。(C)2000年东北大学医科出版社。
Autologous iris pigment epithelial cell transplantation mas performed on patients with exudative age-related macular degeneration (AMD). Autologous IPE cell culture mas performed using autologous serum after iridectomy in 7 patients with AMD. The cell suspensions (2 similar to 20 x 10(4) cells) mere transplanted into the submacular lesion of individuals after removal of neovascular membranes. Subsequent ophthalmological examinations, including best corrected visual acuity and fluorescein or indocyanine green angiography, were performed. In addition, 15 patients with AMD, who underwent removal of neovascular membrane without transplantation, mere evaluated as non randomized controls. Varying degrees of atrophy or defects of choriocapillaris and retinal pigment epithelium mere observed in all of the patients. No cystoid macular edema or fluorescein leakage was observed after treatment, but window defects mere present. No patient had decreased visual acuity. One treated patient developed mild subretinal fibrosis and an other patient developed mild preretinal fibrosis, however no difference was significant when compared with the control. In coclusion, the treatment resulted in no significant improvement in macular function, as compared with the control; however, no rejection or deterioration in visual acuity occurred up to the 13 month follow up. (C) 2000 Tohoku University Medical Press.