Hemophagocytic syndrome after Kawasaki disease.
Hemophagocytic syndrome after Kawasaki disease.
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川崎病后的噬血细胞综合征。
DOI：
10.1097/01.inf.0000073061.55674.1b
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
S. Kaplan
中科院分区：
文献类型：
--
作者：
D. Palazzi;K. McClain;S. Kaplan
噬血细胞综合征（HPS）是一种罕见且危及生命的疾病，其全身性组织细胞增殖导致噬血细胞增多和炎症细胞因子上调。这种综合征与感染、恶性肿瘤、药物和免疫触发因素如川崎病（KD）有关。我们描述了两名儿童在KD后患有HPS的临床和实验室特征，并回顾了先前报道的三例儿童HD复发导致HPS的病例。
Hemophagocytic syndrome (HPS) is a rare and life-threatening disease in which a generalized histiocytic proliferation results in hemophagocytosis and up-regulation of inflammatory cytokines. This syndrome has been associated with infections, malignancy, drugs and immunologic triggers such as Kawasaki disease (KD). We describe the clinical and laboratory features of two children with HPS after KD and review the three previously reported pediatric cases of recrudescence of HD leading to HPS.