PREVALENCE OF CARDIAC ABNORMALITIES IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTION
PREVALENCE OF CARDIAC ABNORMALITIES IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTION
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DOI：
10.1016/0002-9149(89)91081-3
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发表时间：
1989-01-01
影响因子：
2.8
通讯作者：
ROSS, AM
中科院分区：
文献类型：
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作者：
LEVY, WS;SIMON, GL;ROSS, AM
人类免疫缺陷病毒（HIV）感染谱中心脏异常的患病率尚不清楚。使用超声心动图、心电图（50例患者）和动态心电图监测（43例患者）对60例连续HIV感染患者进行了研究。A组（25例患者）为血清学阳性但为AIDS前期患者，而B组（35例患者）患有AIDS，包括24例活动性机会性感染（B1组）和11例无活动性机会性感染（B2组）。60例患者中有32例（53%）发现了腹泻，B组（23/35，66%）比A组（9/25，36%，p < 0.05）更常见，但与活动性机会性感染无关（B1组15/24，62% vs B2组8/11，73%）。60例患者中有21例（35%）发现超声心动图异常，包括A组25例中的7例（28%）和B组35例中的14例（40%）（差异不显著），B1组24例中的7例（29%）和B2组11例中的7例（64%）（差异不显著）。绝对CD 4淋巴细胞计数≤ 100/mm 3的患者的超声心动图异常发生率（22例中的12例）高于CD 4计数>100/mm 3的患者（14例中的1例，p < 0.01）。60例患者中有14例（23%）发现左心室扩张或运动功能减退，其中A组25例中有4例（16%），B组35例中有10例（29%）。50例患者中有22例（44%）出现心电图异常，其中A组18例中有5例（28%），B组32例中有17例（53%）（差异不显著）。因此，心脏异常是HIV阳性患者的常见发现，包括那些没有机会性感染的患者。这表明艾滋病毒可能是一种心脏病原体。
The prevalence of cardiac abnormalities in the spectrum of human immunodeficiency virus (HIV) infection is unknown. Sixty consecutive HIV-infected patients were studied using echocardiograms, electrocardiograms (50 patients) and ambulatory electrocardiographic monitoring (43 patients). Group A (25 patients) were seropositive but pre-AIDS, whereas group B (35 patients) had AIDS and included 24 with an active opportunistic infection (group B1) and 11 without it (group B2). Abnormalities were identified in 32 of 60 patients (53%) and were more frequent in group B (23 of 35, 66%) than in group A (9 of 25, 36%, p < 0.05) but independent of active opportunistic infection (15 of 24, 62%, in group B1 vs 8 of 11, 73%, in group B2). Echocardiographic abnormalities were identified in 21 of 60 patients (35%), including 7 of 25 (28%) in group A vs 14 of 35 (40%) in group B (difference not significant), and 7 of 24 (29%) in group B1 vs 7 of 11 (64%) in group B2 (difference not significant). Those patients with an absolute CD4 lymphocyte count .ltoreq.100/mm3 had a higher prevalence of echocardiographic abnormalities (12 of 22) than those with CD4 counts >100/mm3 (1 of 14, p < 0.01). Left ventricular dilation or hypokinesis was identified in 14 of 60 patients (23%), including 4 of 25 (16%) in group A and 10 of 35 (29%) in group B. Electrocardiographic abnormalities were seen in 22 of 50 patients (44%) including 5 of 18 (28%) in group A and 17 of 32 (53%) in group B (difference not significant). Cardiac abnormalities are thus a frequent finding in HIV-positive patients, including those free of opportunistic infection. This suggests that the HIV may be a cardiac pathogen.