A Cobalt (II) Oxide Carbon Nanotube Composite to Assay Dopamine
A Cobalt (II) Oxide Carbon Nanotube Composite to Assay Dopamine
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DOI：
10.3390/chemosensors8020022
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发表时间：
2020-03
期刊：
影响因子：
4.2
通讯作者：
Mohammad S. Kader;C. C. Chusuei-C.
中科院分区：
文献类型：
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作者：
Mohammad S. Kader;C. C. Chusuei-C.
制备了一种钴氧化物/羧酸功能化多壁碳纳米管（CoO/COOH-MWNT）复合材料，用于多巴胺（DA）的生化检测。通过超声处理将CoO颗粒栓系到COOH-MWNT上。使用循环伏安法测量电流响应对不同浓度。改变各种参数，包括超声处理时间、pH和负载，以获得最佳电流响应。具有最佳电流响应的复合物使用30分钟的超声处理时间，在pH 5.0和0.89 µg/mm 2的负载到玻碳电极表面上形成。该方法灵敏度高，检测限为0.61 ± 0.03 μM，动态范围为10-100 μM，适用于神经母细胞瘤的筛查。该传感器对抗坏血酸和尿酸具有选择性。
A cobalt (II) oxide/carboxylic acid functionalized multiwalled carbon nanotube (CoO/COOH-MWNT) composite was fabricated for the biochemical detection of dopamine (DA). CoO particles were tethered to COOH-MWNTs by sonication. The current response versus different concentration was measured using cyclic voltammetry. Various parameters, including sonication time, pH, and loading were varied for the best current response. The composite with optimum current response was formed using a 30-min sonication time, at pH 5.0 and a 0.89 µg/mm2 loading onto the glassy carbon electrode surface. Good sensitivity with a limit of detection of 0.61 ± 0.03 μM, and dynamic range of 10–100 µM for DA is shown, applicable for neuroblastoma screening. The sensor was selective against ascorbic and uric acids.