Delayed feeding of a high-sucrose diet led to increased body weight by affecting the circadian rhythm of body temperature and hepatic lipid-metabolism genes in rats
Delayed feeding of a high-sucrose diet led to increased body weight by affecting the circadian rhythm of body temperature and hepatic lipid-metabolism genes in rats
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延迟喂养高蔗糖饮食通过影响大鼠体温昼夜节律和肝脏脂质代谢基因导致体重增加
DOI：
10.1016/j.jnutbio.2022.109185
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Kim;D.;Hanzawa;F.;Shimizu;H.;Sun;S.;Umeki;M.;Ikeda;S.;Mochizuki;S. and Oda;H.
不吃早餐是一种不规律的饮食行为，尤其是在年轻人中。在我们之前的研究中，我们建立了大鼠延迟4 h喂养方案作为不吃早餐的模型，并表明延迟4 h喂养高脂肪饮食会导致大鼠体重增加。过量的蔗糖可诱发代谢综合征和脂肪肝。最近，过量的蔗糖摄入受到了越来越多的关注。年轻人通常比成年人摄入更多的糖。在本研究中，我们研究了延迟4 h喂养是否会促进高蔗糖饮食引起的大鼠脂质代谢异常，如脂肪肝和肥胖。延迟喂养4 h的大鼠体重增加，但与正常喂养的大鼠相比，没有引起脂肪肝和高脂血症。饲喂期大鼠血清胰岛素浓度高于对照组，提示延迟4 h饲喂引起了轻微的胰岛素抵抗。由于进食延迟4小时，体温的升高也延迟了4小时。这种延迟会减少增加体重所需的能量消耗。肝脏脂质和葡萄糖代谢相关基因表达的振荡延迟了近2 - 4小时，时钟基因延迟了约2小时。在高糖饮食中，4小时的延迟喂养通过影响体温、胰岛素抵抗和脂质代谢相关基因的昼夜节律振荡导致体重增加，这表明高糖摄入和不吃早餐导致肥胖。
Skipping breakfast is an irregular feeding behavior, typically in young people. In our previous study, we established a 4 h-delayed feeding protocol for rats as a breakfast-skipping model and showed that the 4 h-delayed feeding of a high-fat diet led to body weight gain in rats. Excess sucrose induces metabolic syndrome and fatty liver. Recently, excess sucrose intake has received increased attention. Young people generally consume more sugar than adults do. In the present study, we investigated whether a 4 h-delayed feeding promoted high-sucrose diet-induced abnormalities in lipid metabolism, such as fatty liver and obesity in rats. The 4 h-delayed feeding rats showed increased body weight gain, although it did not induce fatty liver and hyperlipidemia compared to normal feeding rats. Serum insulin concentration during the feeding period was higher than in the control rats, suggesting that slight insulin resistance was induced by the 4 h-delayed feeding. The surge in body temperature was also delayed by 4 h in response to the 4 h-delayed feeding. This delay would result in less energy expenditure to increase body weight. The oscillations of hepatic lipid and glucose metabolism-related gene expression were delayed by almost 2–4 h, and the clock genes were delayed by approximately 2 h. The 4 h-delayed feeding induced weight gain by affecting body temperature, insulin resistance, and circadian oscillation of lipid metabolism-related genes in rats fed a high-sucrose diet, suggesting that a high sucrose intake with breakfast skipping leads to obesity.