RADIATION RISK OF MALIGNANT NEOPLASMS IN ORGANS OF MAIN DEPOSITION FOR PLUTONIUM IN THE COHORT OF MAYAK WORKERS WITH REGARD TO HISTOLOGICAL TYPES
RADIATION RISK OF MALIGNANT NEOPLASMS IN ORGANS OF MAIN DEPOSITION FOR PLUTONIUM IN THE COHORT OF MAYAK WORKERS WITH REGARD TO HISTOLOGICAL TYPES
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DOI：
10.1097/hp.0b013e31828f57df
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发表时间：
2013-08-01
期刊：
影响因子：
2.2
通讯作者：
Koshurnikova, N. A.
中科院分区：
文献类型：
--
作者：
Labutina, E. V.;Kuznetsova, I. S.;Koshurnikova, N. A.
本文介绍了马亚克核工作人员暴露于内部结合钚和外部γ辐射的肺、肝、骨和相关结缔组织中恶性肿瘤发病率的分析结果。研究队列包括1948-1982年期间在马亚克核设施的反应堆、放射化学和钚生产设施工作的22 373人，并跟踪调查到2004年底。所有分析均通过泊松回归进行，使用的剂量是使用最近可用的器官剂量更新（Mayak doses-2008）得出的。有明确的证据表明，体内钚剂量与肺癌风险之间存在线性关系。对于男性，有证据表明，评价的所有组织学类型的肺癌均存在显著的内部钚剂量反应（腺癌、鳞状细胞和其他上皮细胞）;腺癌的估计超额相对危险度（ERR）/戈伊最大（ERR/戈伊= 32.5; 95%CI：16.3; 71.9），约为鳞状细胞肺癌（ERR/戈伊= 3.1; 95%CI：0.3; 9.1）的11倍。肝癌风险与钚暴露之间的关系最好用线性二次（LQ）函数来描述，但在限制内剂量4戈伊后，LQ效应减弱。对于骨和相关结缔组织的恶性肿瘤，这种趋势在统计学上与内部钚剂量无关，但在1950年以前委托的最危险的钚生产设施中雇用的未受监测的女性钚工人中发现了统计学上显著较高的风险（RR=13.7; 95%CI =3.0; 58.5）。
This paper presents the results of analyses of the incidence of malignant neoplasms in lung, liver, and bone and associated connective tissues among Mayak nuclear workers exposed to both internally incorporated plutonium and to external gamma radiation. The study cohort included 22,373 individuals employed at the reactors and radiochemical and plutonium production facilities of the Mayak nuclear complex during 1948-1982 and followed up to the end of 2004. All analyses were carried out by Poisson regression, and the doses used were derived using a recently available update of organ doses, Mayak doses-2008. There was clear evidence for the linear association between internal plutonium dose and the risk of lung cancer. For males, there was evidence of a significant internal plutonium dose response for all histological types of lung cancer evaluated (adenocarcinoma, squamous-cell, and other epithelial); the estimated excess relative risk (ERR)/Gy for adenocarcinoma was the largest (ERR/Gy = 32.5; 95% CI: 16.3; 71.9), about 11-fold higher than that for squamous-cell lung cancer (ERR/Gy = 3.1; 95% CI: 0.3; 9.1). The relationship between liver cancer risk and plutonium exposure was best described by a linear-quadratic (LQ) function, but the LQ effect was diminished after restricting internal doses 4 Gy). For malignant neoplasms of bone and associated connective tissues, the trend was not statistically significant in relation to internal plutonium dose, but a statistically significantly higher risk (RR=13.7; 95% CI=3.0; 58.5) was found among unmonitored female plutonium workers who were employed in the most hazardous plutonium production facility commissioned prior to 1950.