Increased cortisol awakening response and afternoon/evening cortisol output in healthy young adults with low early life parental care
Increased cortisol awakening response and afternoon/evening cortisol output in healthy young adults with low early life parental care
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DOI：
10.1007/s00213-010-1918-4
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发表时间：
2011-03-01
影响因子：
3.4
通讯作者：
Pruessner, Jens C.
中科院分区：
文献类型：
--
作者：
Engert, Veronika;Efanov, Simona I.;Pruessner, Jens C.
越来越多的动物和人类研究证据表明，早期生活经历--从养育行为的变化到严重的逆境--对下丘脑-垂体-肾上腺轴功能有着深远而持久的影响。当前研究的目的是检验早期生活中父母照顾的自然发生变化与皮质醇觉醒反应（CAR）之间的关系，健康年轻人样本中下午/晚上皮质醇输出和关键心理变量。58年龄在18至30岁之间的参与者（19名男性和39名女性）完成了心理问卷，并在醒来时收集了唾液，30分钟后和下午3点，下午6时，和9点在三个非连续的工作日。参与者与低（相比高）的父母照顾的经验表现出增加CAR，增加下午/晚上皮质醇输出，降低自尊，并增加抑郁症和anxiety.We建议，升高CAR和下午/晚上皮质醇水平可能反映了一个生物学的相关性的不利因素引起的精神病理学的脆弱性。这项研究首次显示了健康年轻人对早期父母照顾的回顾性感知与皮质醇昼夜节律之间的关联。
Growing evidence from animal and human studies suggests a profound and long-lasting influence of early life experiences-ranging from variations in parenting behavior to severe adversity-on hypothalamic-pituitary-adrenal axis function.The aim of the current investigation was to examine the association between naturally occurring variations in early life parental care and the cortisol awakening response (CAR), afternoon/evening cortisol output and key psychological variables in a sample of healthy young adults.Fifty-eight (19 male and 39 female) participants between 18 and 30 years of age completed psychological questionnaires and collected saliva at awakening, 30 min thereafter and at 3 p.m., 6 p.m., and 9 p.m. on three non-consecutive weekdays.Participants with low (compared to high) parental care experiences exhibited an increased CAR, increased afternoon/evening cortisol output, decreased self-esteem, and increased depressive symptomatology and anxiety.We suggest that the elevated CAR and afternoon/evening cortisol levels might reflect a biological correlate of adversity-induced vulnerability for psychopathology. This study is first to show an association between the retrospective perception of early life parental care and cortisol circadian rhythms in healthy young adults.