Coronary microcirculation in health and disease. Summary of an NHLBI workshop.
Coronary microcirculation in health and disease. Summary of an NHLBI workshop.
复制标题
健康和疾病中的冠状动脉微循环。
DOI：
10.1161/01.cir.95.2.522
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发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
Chilian,WM
中科院分区：
文献类型：
--
作者：
Chilian,WM
本文总结了1994年9月在马里兰州贝塞斯达举行的为期两天的关于冠状动脉微循环的研讨会，该研讨会由美国国立卫生研究院国家心肺和血液研究所主办。研讨会探讨了与冠状动脉微血管生理学和病理生理学有关的各种主题。讨论了用于研究冠状动脉微血管的最新方法，包括壁内冠状动脉微血管的内窥镜显微镜和微X-射线计算机断层扫描。报道了冠状动脉微循环调节的最新进展，例如肌源性和血流依赖性反应、KATP通道和区域异质性。研讨会讨论了微循环与临床重要疾病的关系，并为这一重要领域的未来研究提供了建议。与外周循环的最新进展和目前我们关于冠状动脉微循环的知识空白进行了比较。近年来，冠脉微循环的研究取得了长足的进步，部分原因是对外周微循环的研究，但也是因为应用了独特的方法。这项研究为研究心肌灌注异常提供了新的方法，直到最近，这一研究领域还仅限于检查冠状动脉压力-血流关系。
This article summarizes a 2-day workshop on the coronary microcirculation held in Bethesda, Md, in September 1994 and sponsored by the National Heart, Lung, and Blood Institute of the National Institutes of Health. The workshop explored a variety of topics pertaining to coronary microvascular physiology and pathophysiology. The latest methodologies that are being used to investigate the coronary microvasculature, including endoscopic microscopy of the intramural coronary microvasculature and micro–x-ray computerized tomography, were discussed. The most recent advances in the regulation of the coronary microcirculation—for example, myogenic and flow-dependent responses, KATPchannels, and regional heterogeneity—were reported. The workshop touched on the relation of the microcirculation to clinically important conditions and offered recommendations for future research in this important area. Comparisons are made to recent advances in the peripheral circulation and current gaps in our knowledge concerning the coronary microcirculation. In recent years, research on the coronary microcirculation has made substantial advances, in part as a result of investigations in the peripheral microcirculation but also because of the application of unique methodologies. This research is providing new ways to investigate abnormalities of myocardial perfusion, an area of inquiry that until recently has been limited to examination of coronary pressure-flow relationships.