Second-generation tissue doppler with angle-corrected color-coded wall displacement for quantitative assessment of regional left ventricular.unction
Second-generation tissue doppler with angle-corrected color-coded wall displacement for quantitative assessment of regional left ventricular.unction
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DOI：
10.1016/s0002-9149(03)00724-0
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发表时间：
2003-09-01
影响因子：
2.8
通讯作者：
Gorcsan, J
中科院分区：
文献类型：
--
作者：
Sade, LE;Severyn, DA;Gorcsan, J
为了验证一种新的组织多普勒（TD）方法，使用角度校正和转换的速度数据的颜色编码的位移数据可以客观地量化区域左心室功能的假设，在体外实验中，首先进行了精确控制的微步进电机的振荡回波目标。位移在1至15 mm（60至130次/min）之间变化，与回波换能器成0和45 °角。定制软件将TD数据转换为位移数据。然后研究了65例受试者：35例室壁运动异常和30例正常对照。结果进行了比较，独立的视觉评估和卡尺测量的内膜偏移的灰度图像。体外位移成像与真实位移密切相关（r = 0.99，p < 0.0001）。在人类中，峰值跨壁位移区分正常结果（6.3 ± 3.2 mm）和运动功能减退（2.7 ± 1.8 mm，p < 0.05），运动不能（0.4 ± 1.2 mm，p < 0.05）和运动功能减退，运动障碍（-1.9 ± 1.2 mm，p < 0.05）和运动不能。正常心内膜下位移为5.9 ± 2.9 mm，心外膜层为4.0 ± 3.9 mm（p < 0.01）。这种位移梯度在异常节段中不存在。位移数据与卡尺测得的内径偏移相关（胸骨旁视图：r = 0.86，所有视图：r = 0.79，均p < 0.0001）。位移成像的总体准确性为82%（kappa = 0.71），而以卡尺数据作为参考标准进行视觉评估的准确性为66%（kappa = 0.43）。角度校正位移成像上级常规视觉评估，是一种有前途的新方法来量化局部左心室功能。(C)2003年，Excerpta Medica，Inc.
To test the hypothesis that a new tissue Doppler (TD) approach using angle-correction and transformation of velocity data to color-coded displacement data may objectively quantify regional left ventricular function, in vitro experiments were first performed with an oscillating echo target precisely controlled by a microstepping motor. Displacement varied from 1 to 15 mm (60 to 130 cycles/min) at angles of 0 and 45 to the echo transducer. Custom software transformed TD data to displacement data. Sixty-five subjects were then studied: 35 with wall motion abnormalities and 30 normal controls. Results were compared with independent visual assessment and caliper measurements of endocardial excursion from gray-scale images. In vitro displacement imaging strongly correlated with true displacement (r = 0.99, p < 0.0001). In humans, peak transmural displacement discriminated normal results (6.3 +/- 3.2 mm) from hypokinesia (2.7 +/- 1.8 mm, p < 0.05), akinesia (0.4 +/- 1.2 mm, p < 0.05) from hypokinesia, and dyskinesia (-1.9 +/- 1.2 mm, p < 0.05) from akinesia. Normal subendocardial displacement was 5.9 +/- 2.9 versus 4.0 +/- 3.9 mm in the epicardial layer (p < 0.01). This displacement gradient was absent in abnormal segments. Displacement data correlated with endocardial excursion by calipers (parasternal views: r = 0.86, all views: r = 0.79, both p < 0.0001). Overall accuracy of displacement imaging was 82% (kappa = 0.71) versus 66% (kappa = 0.43) for visual assessment with caliper data as the standard of reference. Angle-corrected displacement imaging was superior to routine visual assessment and is a promising new method to quantify regional left ventricular function. (C) 2003 by Excerpta Medica, Inc.