New ways of thinking about (and teaching about) intestinal epithelial function
New ways of thinking about (and teaching about) intestinal epithelial function
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DOI：
10.1152/advan.00092.2007
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发表时间：
2008-03-01
影响因子：
2.1
通讯作者：
Barrett, Kim E.
中科院分区：
文献类型：
--
作者：
Barrett, Kim E.
本文总结了在美国生理学会教学进修课程，这是在实验生物学会议在2007年举行的报告。肠上皮具有重要的离子转运和屏障功能，其对肠和其他身体系统的正常生理功能起关键作用。这些功能也经常是功能障碍的目标，反过来，导致特定的消化系统疾病状态，如消化道疾病。三个新兴的概念进行了讨论，离子转运：复杂的相互作用的细胞内信号，既激活和抑制氯化物分泌的多蛋白复合物在离子转运的调节中的作用，以钠/氢交换为例;和急性和慢性调节结肠钠吸收，涉及钠通道内化和从头合成的新通道。同样，最近获得的信息上皮细胞紧密连接的分子组成部分和紧密连接的方式，在健康和疾病的调节进行了讨论，以探讨如何教有关肠屏障性能。最后，遗传决定的肠道疾病和那些由于感染和/或炎症引起的描述，这些可以被用来作为手段，以提高有关肠上皮生理学的教学的基本和临床相关性，以及这种生理学的理解已经对相关的治疗的影响。文章还指出，在相关的地方，如何不同的方法可以有效地用来教相关的概念，研究生与医学/专业学生的观众。
This article summarizes a presentation made at the Teaching Refresher Course of the American Physiological Society, which was held at the Experimental Biology meeting in 2007. The intestinal epithelium has important ion transport and barrier functions that contribute pivotally to normal physiological functioning of the intestine and other body systems. These functions are also frequently the target of dysfunction that, in turn, results in specific digestive disease states, such as diarrheal illnesses. Three emerging concepts are discussed with respect to ion transport: the complex interplay of intracellular signals that both activate and inhibit chloride secretion; the role of multiprotein complexes in the regulation of ion transport, taking sodium/hydrogen exchange as an example; and acute and chronic regulation of colonic sodium absorption, involving both sodium channel internalization and de novo synthesis of new channels. Similarly, recently obtained information about the molecular components of epithelial tight junctions and the ways in which tight junctions are regulated both in health and disease are discussed to exemplify ways to teach about intestinal barrier properties. Finally, both genetically determined intestinal diseases and those arising as a result of infections and/or inflammation are described, and these can be used as the means to enhance the basic and clinical relevance of teaching about intestinal epithelial physiology as well as the impact that the understanding of such physiology has had on associated therapeutics. The article also indicates, where relevant, how different approaches may be used effectively to teach related concepts to graduate versus medical/professional student audiences.