Aligned carbon nanotubes on quartz substrate for liquid gated biosensing
Aligned carbon nanotubes on quartz substrate for liquid gated biosensing
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DOI：
10.1016/j.bios.2010.01.009
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发表时间：
2010-04-15
影响因子：
12.6
通讯作者：
Mhaisalkar, S. G.
中科院分区：
文献类型：
--
作者：
Palaniappan, Al;Goh, W. H.;Mhaisalkar, S. G.
本文报道了一种基于石英衬底上定向碳纳米管的简易、高性能生物传感平台。单壁碳纳米管生长在石英衬底上的化学气相沉积过程，其特征在于与场发射扫描电子显微镜和原子力显微镜，以验证材料的质量。石英衬底然后直接用作场效应晶体管配置中的生物传感器。为了证明所制造的传感器器件的传感能力，通过采用液体门控配置来进行前列腺特异性抗原（潜在的癌症生物标志物）的电子检测。由于靶抗原与固定化受体抗体的特异性结合而引起的电导率变化证明了所制造的装置的感测能力。使用所采用的直接免疫测定方法已经获得了亚nM检测灵敏度，这表明该装置对临床相关浓度方案做出响应。(c)2010爱思唯尔有限公司版权所有。
A facile and high performance biosensing platform using aligned carbon nanotubes on quartz substrate is reported in this communication. Single walled carbon nanotubes are grown on quartz substrates by a chemical vapor deposition process and are characterized with field emission scanning electron microscopy and atomic force microscopy in order to verify the quality of the material. The quartz substrate is then directly used as a biosensor in a field effect transistor configuration. In order to demonstrate the sensing capabilities of the fabricated sensor devices, electronic detection of prostate specific antigen, a potential cancer biomarker, is carried out by adopting liquid gated configuration. A conductivity change due to the specific binding of target antigen with the immobilized receptor antibody demonstrates the sensing capabilities of the fabricated device. Sub-nM detection sensitivities have been obtained using the adopted direct immunoassay approach, which shows that the device responds to clinically relevant concentration regimes. (c) 2010 Elsevier B.V. All rights reserved.