Determinants of oxidative stress among indigenous populations in Northern Laos: Trace element exposures and dietary patterns
Determinants of oxidative stress among indigenous populations in Northern Laos: Trace element exposures and dietary patterns
复制标题
老挝北部土著居民氧化应激的决定因素：微量元素暴露和饮食模式
DOI：
10.1016/j.scitotenv.2023.161516
复制
发表时间：
2023
影响因子：
9.8
通讯作者：
Umezaki Masahiro
中科院分区：
文献类型：
--
作者：
Mizuno Yuki;Inaba Yohei;Masuoka Hiroaki;Kibe Mihoko;Kosaka Satoko;Natsuhara Kazumi;Hirayama Kazuhiro;Inthavong Nouhak;Kounnavong Sengchanh;Tomita Shinsuke;Umezaki Masahiro
ObjectivesTo探讨土著人群中氧化应激的决定因素，我们研究了微量元素暴露和饮食模式与土著人群中三个氧化应激相关的生物标志物之间的关联在北方Laois.MethodsThis横断面研究包括341名成年人从三个村庄不同水平的现代化。我们使用了三种氧化应激相关的生物标志物：尿中8-羟基-2 ′-脱氧鸟苷（8-OHdG）和8-异前列腺素浓度，采用液相色谱-串联质谱法测量，血液端粒长度，采用定量聚合酶链反应方法测量。我们采用多层次分析，以研究协会尿砷，镉，硒浓度，其相互作用的条款，和野生植物食品分数（主成分分数从食物消费频率计算）与氧化应激相关的biomarkers.ResultsUrinary砷和镉浓度呈正相关与尿8-异前列烷浓度。尿硒浓度与尿8-OHdG浓度呈正相关。相互作用项（[砷或镉] ×硒）分别与尿8-OHdG和8-异前列腺素浓度呈负相关。尿镉浓度与端粒长度呈负相关。野生植物食物分数没有表现出与氧化应激相关的生物标志物。ConclusionOur研究结果表明，暴露于砷和镉与更大的氧化脂质损伤，而硒可能会减弱砷诱导的氧化DNA损伤和镉诱导的氧化脂质损伤。镉暴露可加速端粒的磨损。微量元素暴露可能是老挝北方土著居民氧化应激的决定因素。
ObjectivesTo investigate determinants of oxidative stress in an indigenous population, we examined associations of trace element exposures and dietary patterns with three oxidative stress-related biomarkers among indigenous populations in Northern Laos.MethodsThis cross-sectional study included 341 adults from three villages with different levels of modernization. We used three oxidative stress-related biomarkers: urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-isoprostane concentrations, which were measured using liquid chromatography-tandem mass spectrometry, and blood telomere lengths, which were measured using a quantitative polymerase chain reaction method. We used multilevel analysis to examine associations of urinary arsenic, cadmium, and selenium concentrations, their interaction terms, and wild-plant-food scores (principal component scores calculated from food consumption frequencies) with oxidative stress-related biomarkers.ResultsUrinary arsenic and cadmium concentrations were positively associated with urinary 8-isoprostane concentrations. Urinary selenium concentrations were positively associated with urinary 8-OHdG concentrations. Interaction terms ([arsenic or cadmium] × selenium) showed negative associations with urinary 8-OHdG and 8-isoprostane concentrations, respectively. Urinary cadmium concentrations were negatively associated with telomere lengths. Wild-plant-food scores did not exhibit associations with oxidative stress-related biomarkers.ConclusionOur findings imply that exposure to arsenic and cadmium is associated with greater oxidative lipid damage, whereas selenium may attenuate arsenic-induced oxidative DNA damage and cadmium-induced oxidative lipid damage. Cadmium exposure may accelerate telomere attrition. Trace element exposure may be a determinant of oxidative stress among indigenous populations in Northern Laos.