A linear relation between the compressibility and density of blood
A linear relation between the compressibility and density of blood
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DOI：
10.1121/1.1333419
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发表时间：
2001-01-01
影响因子：
2.4
通讯作者：
Lee, JS
中科院分区：
文献类型：
--
作者：
Wang, SH;Lee, LP;Lee, JS
通过将血液视为超滤液和蛋白质浓缩物的混合物，利用各成分的可压缩性和密度的相加性质来推导出血液的可压缩性和密度之间的线性关系。这一推导还表明，线性关系的截距和斜率与红细胞的血细胞比容、血浆蛋白浓度和血红蛋白浓度无关。为了通过实验验证这种线性关系，对体外回路中流动的猪或犬血液进行了盐水和血浆稀释。实验的血细胞比容范围为0%至55%，血浆蛋白浓度范围为10至90 g/l。电路中的谐振装置测量 37 摄氏度下血液的密度 rho (b)，超声系统测量声速 cb。密度范围为1010至1060g/l，声速范围为1530至1580m/s。最适合压缩性数据[计算为(p(b)C(b)(2))(-1)]和密度的线性关系的相关系数为0.9978。发现线性关系很好地拟合了文献中人、马和猪血液的声速数据得出的压缩率对密度的依赖性。 (C) 2001 年美国声学学会。
By considering the blood as a mixture of ultrafiltrate and protein concentrate, the additive nature of compressibility and density from the components is utilized to deduce a linear relation between the compressibility and density for blood. This deduction also indicates that the intercept and slope of the linear relation are independent of the hematocrit, plasma protein concentration, and hemoglobin concentration of red blood cells. To verify experimentally this linear relation, saline and plasma dilutions on porcine or canine blood flowing in an extracorporeal circuit were carried out. The hematocrit of the experiments ranges from 0% to 55% and the plasma protein concentration ranges from 10 to 90 g/l. A resonance device in the circuit measured the density rho (b), of blood at 37 degreesC and an ultrasound system measured the sound velocity cb. The range of density is from 1010 to 1060 g/l and that of sound velocity is from 1530 to 1580 m/s. The linear relation that best fits the data of compressibility [computed as (p(b)C(b)(2))(-1)] and density has a correlation coefficient of 0.9978. The linear relation is found to fit well the dependence of compressibility on density derived from the sound velocity data of human, horse, and porcine blood in the literature. (C) 2001 Acoustical Society of American.