In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women.
In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women.
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DOI：
10.1007/s10439-009-9850-7
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发表时间：
2010-02
影响因子：
3.8
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Goldenstein, Janet;Kazakia, Galateia;Majumdar, Sharmila
这是第一项观察性研究，检查绝经后骨质疏松症妇女体内皮质孔隙率，并纳入两种不同成像方式的数据，以进一步检查皮质孔隙率的性质。本研究的目的是结合联合收割机高分辨率外周计算机断层扫描（HR-pQCT）图像（包含皮质结构的高空间分辨率信息）和磁共振（MR）图像（可显示软组织（如骨髓）），观察绝经后骨质疏松症女性中包含骨髓的皮质孔隙量。采用HR-pQCT和MR成像扫描49例桡骨和51例绝经后骨质疏松妇女（年龄56 ± 3.7）的胫骨。使用归一化互信息配准算法来获得将MR图像与HR-pQCT图像对准的三维刚性变换。对齐的图像允许皮质孔中骨髓的可视化。根据HR-pQCT图像，确定皮质孔隙率百分比、皮质孔数量和每个皮质孔的大小。通过重叠对齐的MR和HR-pQCT图像，测量包含骨髓的皮质孔的百分比、包含骨髓的皮质孔的数量以及包含骨髓的每个皮质孔的尺寸。虽然受试者之间的皮质孔隙量变化不大，但受试者之间的皮质孔隙类型（含骨髓与不含骨髓）变化很大。结果表明，皮质孔隙空间包含不同的组成成分，并可能有一个以上的机制皮质孔隙度的发展。
This is the first observational study examining cortical porosity in vivo in postmenopausal osteopenic women and to incorporate data from two different imaging modalities to further examine the nature of cortical porosity. The goal of this study was to combine high-resolution peripheral computed tomography (HR-pQCT) images, which contain high spatial resolution information of the cortical structure, and magnetic resonance (MR) images, which allow the visualization of soft tissues such as bone marrow, to observe the amount of cortical porosity that contains bone marrow in postmenopausal osteopenic women. The radius of 49 and the tibia of 51 postmenopausal osteopenic women (age 56 ± 3.7) were scanned using both HR-pQCT and MR imaging. A normalized mutual information registration algorithm was used to obtain a three-dimensional rigid transform which aligned the MR image to the HR-pQCT image. The aligned images allowed for the visualization of bone marrow in cortical pores. From the HR-pQCT image, the percent cortical porosity, the number of cortical pores, and the size of each cortical pore was determined. By overlaying the aligned MR and HR-pQCT images, the percent of cortical pores containing marrow, the number of cortical pores containing marrow, and the size of each cortical pore containing marrow were measured. While the amount of cortical porosity did not vary greatly between subjects, the type of cortical pore, containing marrow vs. not containing marrow, varied highly between subjects. The results suggest that cortical pore spaces contain components of varying composition, and that there may be more than one mechanism for the development of cortical porosity.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.2106/00004623-197658010-00015
发表时间：
1976-01-01
影响因子：
5.3
作者：
BURSTEIN, AH;REILLY, DT;MARTENS, M
通讯作者：
MARTENS, M
影响因子：
10.6
作者：
Holden, M;Hill, DLG;Hawkes, DJ
通讯作者：
Hawkes, DJ
影响因子：
6.2
作者：
Greenspan, SL;Beck, TJ;Parker, RA
通讯作者：
Parker, RA
影响因子：
4.2
作者：
Davis, Kevin A.;Burghardt, Andrew J.;Majumdar, Sharmila
通讯作者：
Majumdar, Sharmila