Seasonality and outbreak of a predominant Streptococcus pneumoniae serotype 1 clone from The Gambia: Expansion of ST217 hypervirulent clonal complex in West Africa
Seasonality and outbreak of a predominant Streptococcus pneumoniae serotype 1 clone from The Gambia: Expansion of ST217 hypervirulent clonal complex in West Africa
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DOI：
10.1186/1471-2180-8-198
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发表时间：
2008-11-17
期刊：
影响因子：
4.2
通讯作者：
Adegbola, Richard A.
中科院分区：
文献类型：
--
作者：
Antonio, Martin;Hakeem, Ishrat;Adegbola, Richard A.
背景：在冈比亚，在所有年龄组中，肺炎链球菌血清1型导致> 20%的侵袭性疾病。相反，它很少在运输研究中检测到。本研究比较了沙门氏菌的分子流行病学。结果：从1996 ~ 2005年冈比亚流行的侵袭性肺炎血清1型和2004 ~ 2006年鼻咽部携带的肺炎血清1型中分离出127株侵袭性肺炎和36株鼻咽部携带肺炎血清1型。MLST分析揭示了23种不同的序列类型（ST），其中18种是新的。在163株分离株中，最流行的克隆是ST 618（70.5%），其次是ST 3575（7.4%）、ST 2084（2.5%）和ST 612（2.5%）。先前显示属于ST 217高毒力克隆复合物的单个ST（ST 618）在携带（61.1%）和侵袭性（72.7%）血清1型分离株中很常见。ST 618引起儿童和成人疾病，每年在干热季节达到高峰，并在1997年和2002年引起暴发流行。结论：10多年来，ST 618菌株一直是冈比亚流行的血清1型携带和疾病菌株的优势谱系。这一谱系显示出与非洲脑膜炎带脑膜炎球菌相似的流行病学特征，能够引起疾病暴发
Background: Streptococcus pneumoniae serotype 1 causes > 20% of invasive disease, among all age groups combined, in The Gambia. In contrast, it is rarely detected in carriage studies. This study compares the molecular epidemiology of S. pneumoniae serotype 1 causing invasive disease in The Gambia between 1996 and 2005 to those carried in the nasopharynx between 2004 and 2006.Results: A total of 127 invasive and 36 nasopharyngeal carriage serotype 1 isolates were recovered from individuals of all age groups and were analyzed by serotyping, antibiotic susceptibility testing and MLST. MLST analysis revealed 23 different sequence types (STs), 18 of which were novel. The most prevalent clone among the 163 isolates was ST618 (70.5%), followed by ST3575 (7.4%), ST2084 (2.5%) and ST612 (2.5%). A single ST (ST618), previously shown to belong to the ST217 hypervirulent clonal complex, was frequent among carriage (61.1%) and invasive (72.7%) serotype 1 isolates. ST618 causing both paediatric and adult disease peaked annually in the hot dry season and caused outbreak in 1997 and 2002.Conclusion: For over a decade, isolates of ST618 have been the dominant lineage among serotype 1 carriage and disease isolates circulating in the Gambia. This lineage shows similar epidemiological features to those of the meningococcus in the African meningitis belt being able to cause outbreaks of disease