Prevalence of Depression in a Large Urban South Indian Population - The Chennai Urban Rural Epidemiology Study (Cures-70)
Prevalence of Depression in a Large Urban South Indian Population - The Chennai Urban Rural Epidemiology Study (Cures-70)
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DOI：
10.1371/journal.pone.0007185
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发表时间：
2009-09-28
期刊：
影响因子：
3.7
通讯作者：
Mohan, Viswanathan
中科院分区：
文献类型：
--
作者：
Poongothai, Subramani;Pradeepa, Rajendra;Mohan, Viswanathan
背景：在印度，关于抑郁症患病率的人口数据很少。这项研究的目的是确定抑郁症的患病率在城市南Indian population.Methods和调查结果：主题是从金奈城市农村流行病学研究（CURES），涉及26,001名受试者随机招募的155个企业病房金奈（原马德拉斯）在印度南部城市的46。25，455例受试者参加了本研究（应答率97.9%）。使用自我报告和先前验证的工具，患者健康问卷（PHQ）-12评估抑郁症。根据2001年印度人口普查进行了年龄调整。抑郁症的总体患病率为15.1%（年龄调整后为15.9%），女性更高（女性16.3% vs.男性13.9%，p < 0.0001）。与男性受试者相比，女性受试者中抑郁症的比值比（OR）为1.20 [置信区间（CI）：1.12-1.28，p < 0.001]。抑郁情绪是最常见的症状（30.8%），其次是疲倦（30.0%），而更严重的症状，如自杀念头（12.4%）和语言和运动迟缓（12.4%）则不太常见。抑郁症患病率随年龄的增长而增加，女性（P < 0.001）和男性（P < 0.001）。低收入组抑郁症患病率（19.3%）高于高收入组（5.9%，p < 0.001）。抑郁症的患病率也较高离婚（26.5%）和丧偶（20%）相比，目前已婚的科目（15.4%，p < 0.001）。结论：这是最大的基于人口的研究，从印度报告的抑郁症的患病率，并显示，在城市南部印度人，抑郁症的患病率为15.1%。年龄，女性性别和较低的社会经济地位是与抑郁症相关的一些因素。
Background: In India there are very few population based data on prevalence of depression. The aim of the study was to determine the prevalence of depression in an urban south Indian population.Methods and Findings: Subjects were recruited from the Chennai Urban Rural Epidemiology Study (CURES), involving 26,001 subjects randomly recruited from 46 of the 155 corporation wards of Chennai (formerly Madras) city in South India. 25,455 subjects participated in this study (response rate 97.9%). Depression was assessed using a self-reported and previously validated instrument, the Patient Health Questionnaire (PHQ) - 12. Age adjustment was made according to the 2001 census of India. The overall prevalence of depression was 15.1% (age-adjusted, 15.9%) and was higher in females (females 16.3% vs. males 13.9%, p < 0.0001). The odds ratio (OR) for depression in female subjects was 1.20 [Confidence Intervals (CI): 1.12-1.28, p < 0.001] compared to male subjects. Depressed mood was the most common symptom (30.8%), followed by tiredness (30.0%) while more severe symptoms such as suicidal thoughts (12.4%) and speech and motor retardation (12.4%) were less common. There was an increasing trend in the prevalence of depression with age among both female (p < 0.001) and male subjects (p < 0.001). The prevalence of depression was higher in the low income group (19.3%) compared to the higher income group (5.9%, p < 0.001). Prevalence of depression was also higher among divorced (26.5%) and widowed (20%) compared to currently married subjects (15.4%, p < 0.001).Conclusions: This is the largest population-based study from India to report on prevalence of depression and shows that among urban south Indians, the prevalence of depression was 15.1%. Age, female gender and lower socio-economic status are some of the factors associated with depression in this population.