Non-feminizing estrogens: a novel neuroprotective therapy.
Non-feminizing estrogens: a novel neuroprotective therapy.
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DOI：
10.1016/j.mce.2013.12.017
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发表时间：
2014-05-25
影响因子：
4.1
通讯作者：
Reed MN
中科院分区：
文献类型：
--
作者：
Petrone AB;Gatson JW;Simpkins JW;Reed MN
虽然雌激素神经保护的基础科学证据与临床试验缺乏有效性之间的冲突现在才得到解决，但很明显，避免ER激活的雌激素神经保护策略具有临床应用的潜力。在此，我们回顾了体外和体内研究的证据，描述了非女性化雌激素的高效神经保护作用。我们已经描述了非雌性化雌激素的许多基本化学特征，这些特征消除或减少ER结合，同时维持或增强神经保护。此外，我们提供的证据表明，这些非女性化雌激素具有保护大脑免受AD神经病理学和创伤性脑损伤的功效。总之，似乎非雌性化雌激素神经保护策略是一种可行的选择，以实现雌激素的有益神经保护作用，同时消除慢性雌激素给药的毒性脱靶效应。
While the conflict between basic science evidence for estrogen neurproprotection and the lack of effectiveness in clinical trials is only now being resolved, it is clear that strategies for estrogen neuroprotection that avoid activation of ERs have the potential for clinical application. Herein we review the evidence from both in vitro and in vivo studies that describe high potency neuroprotection with non-feminizing estrogens. We have characterized many of the essential chemical features of non-feminizing estrogens that eliminate or reduce ER binding while maintaining or enhancing neuroprotection. Additionally, we provide evidence that these non-feminizing estrogens have efficacy in protecting the brain from AD neuropathology and traumatic brain injury. In conclusion, it appears that the non-feminizing estrogen strategy for neuroprotection is a viable option to achieve the beneficial neuroprotective effects of estrogens while eliminating the toxic off-target effects of chronic estrogen administration.
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影响因子：
3.3
作者：
Green, PS;Gridley, KE;Simpkins, JW
通讯作者：
Simpkins, JW
影响因子：
5.3
作者：
Alkayed, NJ;Goto, S;Hurn, PD
通讯作者：
Hurn, PD
DOI：
10.1016/s0960-0760(01)00190-x
发表时间：
2002-02-01
影响因子：
4.1
作者：
Filardo, EJ
通讯作者：
Filardo, EJ
影响因子：
5.3
作者：
Carroll, Jenna C.;Rosario, Emily R.;Pike, Christian J.
通讯作者：
Pike, Christian J.
影响因子：
3.3
作者：
Goodenough, S;Schleusner, D;Behl, C
通讯作者：
Behl, C