Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase
Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase
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DOI：
10.1111/j.1567-1364.2008.00406.x
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发表时间：
2008-08-01
影响因子：
3.2
通讯作者：
Honigberg, Saul M.
中科院分区：
文献类型：
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作者：
Gray, Misa;Piccirillo, Sarah;Honigberg, Saul M.
葡萄糖诱导途径的几个组成部分，即Snf3p葡萄糖传感器和Rgt1p和Mth1p转录因子，被证明参与葡萄糖抑制孢子形成。葡萄糖传感器在调节减数分裂起始的两个关键调节因子Ime1p转录因子和Ime2p激酶的转录水平方面仅起次要作用，但在调节Ime2p稳定性方面起主要作用。有趣的是，Rgt1p参与葡萄糖对孢子形成的抑制，但不参与Ime2p稳定性的抑制。因此，葡萄糖诱导途径可能通过rgt1依赖性和rgt1非依赖性途径调控减数分裂。
Several components of the glucose induction pathway, namely the Snf3p glucose sensor and the Rgt1p and Mth1p transcription factors, were shown to be involved in inhibition of sporulation by glucose. The glucose sensors had only a minor role in regulating transcript levels of the two key regulators of meiotic initiation, the Ime1p transcription factor and the Ime2p kinase, but a major role in regulating Ime2p stability. Interestingly, Rgt1p was involved in glucose inhibition of spore formation but not inhibition of Ime2p stability. Thus, the glucose induction pathway may regulate meiosis through both RGT1-dependent and RGT1-independent pathways.