Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited
Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited
复制标题
DOI：
10.1177/0961203313500550
复制
发表时间：
2013-11-01
期刊：
影响因子：
2.6
通讯作者：
Mok, C. C.
中科院分区：
文献类型：
--
作者：
Chan, K. L.;Mok, C. C.
Systemic lupus erythematosus (SLE) predominantly affects women of childbearing age. The infrequency of SLE in men and disease onset in prepubertal or postmenopausal women suggests a role of estrogen in the predisposition to the disease. Patients with hypergonadotrophic hypogonadism are prone to the development of SLE, and the use of exogenous estrogens in women increases the relative risk of SLE onset and disease flares. These observations provide indirect evidence for an opposite role of estrogens and androgens in the pathogenesis of SLE. We report on a male-to-female transsexual who developed SLE 20 years after sex-reassignment surgery and prolonged estrogen therapy. The role of sex hormones in SLE is revisited.
