Where Did SARS-CoV-2 Come From?
Where Did SARS-CoV-2 Come From?
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DOI：
10.1093/molbev/msaa162
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发表时间：
2020-09-01
影响因子：
10.7
通讯作者：
Kumar, Sudhir
中科院分区：
文献类型：
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作者：
Leitner, Thomas;Kumar, Sudhir
确定SARS-CoV-2（当前COVID-19大流行的病原体）的起源可能有助于我们避免未来冠状病毒和其他人畜共患病的流行。关于SARS-CoV-2的人畜共患病起源的几种理论最近被提出。尽管在中国菊头蝠中发现的β冠状病毒已被广泛牵连，但它们与SARS-CoV-2的遗传差异如此之高，以至于它们极不可能是其直接祖先。因此，怀疑中间宿主将蝙蝠与人类冠状病毒联系起来。基于来自不同宿主的不同冠状病毒的基因组CpG二核苷酸模式，人们认为SARS-CoV-2可能在传播给人类之前在犬科动物的胃肠道中进化。然而，现在在来自其他宿主的冠状病毒中报道了类似的CpG模式，包括蝙蝠本身和穿山甲。因此，单独的减少的基因组CpG不是高度预测性的生物标志物，表明需要额外的生物标志物来揭示中间宿主或组织。寻找SARS-CoV-2的人畜共患病起源仍在继续。
Identifying the origin of SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, may help us to avoid future epidemics of coronavirus and other zoonoses. Several theories about the zoonotic origin of SARS-CoV-2 have recently been proposed. Although Betacoronavirus found in Rhinolophus bats from China have been broadly implicated, their genetic dissimilarity to SARS-CoV-2 is so high that they are highly unlikely to be its direct ancestors. Thus, an intermediary host is suspected to link bat to human coronaviruses. Based on genomic CpG dinucleotide patterns in different coronaviruses from different hosts, it was suggested that SARS-CoV-2 might have evolved in a canid gastrointestinal tract prior to transmission to humans. However, similar CpG patterns are now reported in coronaviruses from other hosts, including bats themselves and pangolins. Therefore, reduced genomic CpG alone is not a highly predictive biomarker, suggesting a need for additional biomarkers to reveal intermediate hosts or tissues. The hunt for the zoonotic origin of SARS-CoV-2 continues.