Palladium-catalyzed Mizoroki-Heck Reaction Using Imidazo[1,5-a]pyridines
Palladium-catalyzed Mizoroki-Heck Reaction Using Imidazo[1,5-a]pyridines
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使用咪唑并[1,5-a]吡啶的钯催化 Mizoroki-Heck 反应
DOI：
10.1002/chem.201604207
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发表时间：
2016
期刊：
影响因子：
2.1
通讯作者：
Yasuhiko Kawamura
中科院分区：
文献类型：
--
作者：
Fumitoshi Yagishita;Koh Nomura;Saki Shiono;Chiho Nii;Takashi Mino;Masami Sakamoto;Yasuhiko Kawamura
在没有外部手性源的情况下，由非手性前体生成单手α-氨基酸衍生物。苯乙胺与非手性芳酰基丙烯酰胺在均相条件下的共轭加成得到定量产率的α-氨基酰胺，其结晶为aP 21晶体系统的聚集体。动态优先结晶或摩擦增强的去外消旋化导致形成99%ee的对映体晶体。
Single‐handed α‐amino acid derivatives were generated from achiral precursors without an external chiral source. Conjugate addition of phenethylamine to an achiral aroyl acrylamide under homogeneous conditions gave the α‐amino amides in quantitative yields, which crystallized as a conglomerate of aP21crystal system. Dynamic preferential crystallization or attrition‐enhanced deracemization resulted in the formation of enantiomorphic crystals of 99 %ee.