Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery
Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery
复制标题
DOI：
10.1002/bip.20989
复制
发表时间：
2008-01-01
期刊：
影响因子：
2.9
通讯作者：
Torchilin, Vladimir P.
中科院分区：
文献类型：
--
作者：
Torchilin, Vladimir P.
包括TAT肽（TATP）的细胞穿透肽（CPP）已成功地用于细胞内递送多种货物，包括各种纳米颗粒药物载体（脂质体、胶束、纳米颗粒）。在这里，我们将考虑在这一领域的主要结果，特别强调TATP介导的脂质体和DNA的传递。我们还将解决“智能”刺激敏感性纳米载体的开发，其中细胞穿透功能仅在生物靶点内通过降低pH值来激活，从而最大限度地减少载药纳米载体与非靶细胞的相互作用。(C)2008 Wiley Periodicals，Inc.
Cell-penetrating peptides (CPPs) including TAT peptide (TATP) have been successfully used for intracellular delivery of a broad variety of cargos including various nanoparticulate pharmaceutical carriers (liposomes, micelles, nanoparticles). Here, we will consider the main results in this area, with a special emphasis on TATp-mediated delivery, of liposomes and DNA. We will also address the development of 'smart" stimuli-sensitive nanocarriers, where cell-penetrating function call be activated by the decreased pH only inside the biological target minimizing thus the interaction of drug-loaded nanocarriers with nontarget cells. (C) 2008 Wiley Periodicals, Inc.