Commonality and specificity of acupuncture action at three acupoints as evidenced by FMRI.
Commonality and specificity of acupuncture action at three acupoints as evidenced by FMRI.
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DOI：
10.1142/s0192415x12500528
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hui KK
中科院分区：
文献类型：
--
作者：
Claunch JD;Chan ST;Nixon EE;Qiu WQ;Sporko T;Dunn JP;Kwong KK;Hui KK
我们团队和其他人之前的工作表明，手动针刺LI4(合谷穴)、ST36(足三里穴)和LV3(太冲穴)可以去激活边缘-边缘-新皮质大脑网络，同时激活大脑的躯体感觉区域。本研究的目的是探讨手针LI4、ST36和LV3穴位的特异性和共性，这些穴位位于不同的经络，用于治疗疼痛障碍。应用功能磁共振成像(FMRI)对针刺3个不同穴位的大脑反应进行监测，对46例健康受试者在针刺过程中根据其心理物理反应感受到去气感觉。每个穴位的大脑对刺激的反应都是相互关联地显示出来的，以显示空间分布。我们发现，在内侧前额叶、内侧顶叶和内侧颞叶，两个或所有三个穴位都有明显的会聚现象。对所有三个穴位都有共同反应的最大区域是右侧膝下BA25、右侧膝下扣带、右侧扣带束右侧峡部和右侧BA31。我们还注意到内侧前额叶和内侧颞叶的主要部分的差异，LI4在主要扣带回和海马结构中占主导地位，ST36在膝下扣带结构中占主导地位，LV3在后海马和后扣带结构中占主导地位。结果表明，虽然这些通常用于止痛和调节作用的穴位可能动员相同的内在全球网络，有大量的共同脑区重叠来调节其作用，但我们的发现显示某些边缘-边缘结构的优先反应表明穴位也可能表现出相对的特异性。
Previous work from our team and others has shown that manual acupuncture at LI4 (hegu), ST36 (zusanli), and LV3 (taichong) deactivates a limbic-paralimbic-neocortical brain network, and at the same time activates somatosensory regions of the brain. The objective of the present study was to explore the specificity and commonality of the brain response to manual acupuncture at LI4, ST36, and LV3, acupoints that are located on different meridians and are used to treat pain disorders. We used functional magnetic resonance imaging (fMRI) to monitor the brain responses to acupuncture at 3 different acupoints; we examined 46 healthy subjects who, according to their psychophysical responses, experienced deqi sensation during acupuncture. Brain responses to stimulation at each of the acupoints were displayed in conjunction with one another to show the spatial distribution. We found clusters of deactivation in the medial prefrontal, medial parietal and medial temporal lobes showing significant convergence of two or all three of the acupoints. The largest regions showing common responses to all three acupoints were the right subgenual BA25, right subgenual cingulate, right isthmus of the cingulum bundle, and right BA31. We also noted differences in major sections of the medial prefrontal and medial temporal lobes, with LI4 predominating in the pregenual cingulate and hippocampal formation, ST36 predominating in the subgenual cingulate, and LV3 predominating in the posterior hippocampus and posterior cingulate. The results suggest that although these acupoints commonly used for anti-pain and modulatory effects may mobilize the same intrinsic global networks, with substantial overlap of common brain regions to mediate its actions, our findings showing preferential response of certain limbic-paralimbic structures suggests acupoints may also exhibit relative specificity.