The effect of highly active antiretroviral therapy on outcome of central nervous system herpesviruses infection in Cuban human immunodeficiency virus-infected individuals
The effect of highly active antiretroviral therapy on outcome of central nervous system herpesviruses infection in Cuban human immunodeficiency virus-infected individuals
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DOI：
10.1080/13550280701510088
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发表时间：
2007-10-01
影响因子：
3.2
通讯作者：
Kourí, Vivian
中科院分区：
文献类型：
--
作者：
Martínez, Pedro Ariel;Díaz, Ren;Kourí, Vivian
随着高效抗逆转录病毒疗法（HAART）的快速发展，人类免疫缺陷病毒（HIV）脑炎的观察模式发生了变化，使疱疹病毒（HV）感染得到控制。HAART于2001年首次在古巴对艾滋病毒患者实施。因此，为了研究后haart时代hv在该人群中引起神经系统疾病的行为，作者通过多重巢式聚合酶链反应（PCR）试验同时检测人类hv -单纯疱疹病毒（HSV）、水痘病毒（VZV）、细胞阴性病毒（CMV）、人类疱疹病毒6 （HHV-6）和eb病毒（EBV）进行了临床评估。作者研究了2001年至2005年间在性传播疾病实验室收到的241份脑脊液样本。在所研究的241例脑脊液中，10.4%的结果为hiv感染阳性。其中，92%的患者为C3期获得性免疫缺陷综合征（AIDS）患者。CMV（44%）、EBV（28%）和双hv（16%）感染是最重要的病原体。主要临床表现为发热、头痛、呕吐和局灶性异常；后者与死亡风险增加有关。在发生脑炎之前，对接受HAART治疗的患者与未接受HAART治疗的患者之间的中枢神经系统（CNS）疾病演变进行比较，观察到具有统计学意义的结果。因此得出的结论是，接受HAART治疗的艾滋病毒感染者比未接受HAART治疗的人更有可能更好地恢复中枢神经系统感染。
With the rapid progress in the development of highly active antiretroviral therapy (HAART), the observed patterns in human immunodeficiency virus (HIV) encephalitis has changed, allowing herpesvirus (HV) infection to be controlled. HAART was first administered to HIV patients in Cuba in 2001. Consequently with the aim of investigate the behavior of the HVs causing neurological disorders in this population in the post-HAART era, the authors perform a clinical evaluation by a multiplex nested polymerase chain reaction (PCR) assay for simultaneous detection of human HVs - herpes simplex virus (HSV), varicellazoster virus (VZV), cytornegalovirus (CMV), human herpesvirus 6 (HHV-6), and Epstein-Barr virus (EBV). The authors studied 241 samples of cerebrospinal fluid (CSF) received at the Sexually Transmitted Diseases Laboratory between 2001 and 2005 inclusive. Of the 241 CSF studied, 10.4% resulted positive for HV infections. Of these, 92% of patients were acquired immunodeficiency syndrome (AIDS) individuals at the C3 stage. CMV (44%), EBV (28%), and dual-HV (16%) infections were the most important agents identified. The principal clinical manifestations were fever, headache, vomiting, and focal abnormalities; the latter being associated with an increased risk of death. A statistically significant result was observed when central nervous system (CNS) disease evolution was compared between patients who were under HAART against those who were not, before they developed encephalitis. It was therefore concluded that it is more likely that HIV individuals receiving HAART have a better recovery of CNS infections than those who are not receiving it.