Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions.
Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions.
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DOI：
10.1038/gene.2013.32
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发表时间：
2013-09
影响因子：
5
通讯作者：
Chen YG
中科院分区：
文献类型：
--
作者：
Tsaih SW;Khaja S;Ciecko AE;MacKinney E;Chen YG
Reduced frequency of invariant natural killer T (iNKT)-cells has been indicated as a contributing factor to type 1 diabetes (T1D) development in NOD mice. To further understand the genetic basis of the defect, we generated (NOD X ICR)F2 mice to map genes that control iNKT-cell development. We determined frequencies of thymic and splenic iNKT-cells as well as the ratio of CD4-positive and -negative subsets in the spleens of 209 F2 males. Quantitative trait loci (QTL) analysis revealed 5 loci that exceed the significant threshold for the frequency of thymic and/or splenic iNKT-cells on Chromosomes (Chr) 1, 5, 6, 12, and 17. Three significant loci on Chr 1, 4, and 5 were found for the ratio of CD4-positive and -negative splenic iNKT-cells. Comparisons to previously known mouse T1D susceptibility (Idd) loci revealed two significant QTL peak locations respectively mapped to Idd regions on Chr 4 and 6. The peak marker location of the significant Chr 12 iNKT QTL maps to within 0.5Mb of a syntenic human T1D locus. Collectively, our results reveal several novel loci controlling iNKT-cell development and provide additional information for future T1D genetic studies.
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影响因子：
4.4
作者：
Matsuki, N;Stanic, AK;Joyce, S
通讯作者：
Joyce, S
影响因子：
4.4
作者：
Jordan, Margaret A.;Fletcher, Julie M.;Baxter, Alan G.
通讯作者：
Baxter, Alan G.
DOI：
10.1084/jem.188.10.1831
发表时间：
1998-11-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1084/jem.187.7.1047
发表时间：
1998-04-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hammond KJ;Poulton LD;Palmisano LJ;Silveira PA;Godfrey DI;Baxter AG
通讯作者：
Baxter AG
影响因子：
4.4
作者：
Fletcher, Julie M.;Jordan, Margaret A.;Baxter, Alan G.
通讯作者：
Baxter, Alan G.