Helicobacter pylori infection among offspring of patients with stomach cancer
Helicobacter pylori infection among offspring of patients with stomach cancer
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DOI：
10.1016/s0016-5085(00)70411-2
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发表时间：
2000-01-01
期刊：
影响因子：
29.4
通讯作者：
Boeing, H
中科院分区：
文献类型：
--
作者：
Brenner, H;Bode, G;Boeing, H
背景和目标：阳性家族史与胃癌风险增加有关。我们比较了父母有和没有胃癌史的受试者之间幽门螺杆菌感染（胃癌的一个已知危险因素）的患病率，以评估H.方法：对1987-1988年在德国西部进行的德国健康与营养调查中的1351名30-74岁的男女进行了研究。通过标准化访谈获得有关社会人口学因素、营养因素和父母癌症史的详细信息。分析血清样本中抗H. pylori的酶联免疫吸附试验。结果如下：父母有胃癌史的受试者中H，pylori感染的患病率（69%）远高于其他受试者（44%）。在控制了潜在的混杂因素后，这种相关性仍然存在（调整后的比值比，2.7; 95%置信区间，1.3-5.9），并且在55岁以下的受试者中特别强（校正比值比，5.1; 95%可信区间，1.6-16.1）。结论：这些结果提示胃癌的家族聚集性至少部分可以用H.幽门感染
Background & Aims: A positive family history is associated with an increased risk of stomach cancer, We compared the prevalence of Helicobacter pylori infection, a known risk factor for stomach cancer, between subjects with and without parental history of stomach cancer to evaluate a potential role of H. pylori infection in familial aggregation of stomach cancer, Methods: A total of 1351 men and women aged 30-74 years who participated in the German Health and Nutrition Survey conducted in the western part of Germany in 1987-1988 were included in the study. Detailed information on sociodemographic factors, nutritional factors, and parental history of cancer was obtained by standardized interviews. Serum samples were analyzed for immunoglobulin G antibodies against H. pylori by enzyme-linked immunosorbent assay. Results: The prevalence of H, pylori infection was much higher (69%) among subjects with a parental history of stomach cancer than among other subjects (44%), This association persisted after control for potential confounders by multiple logistic regression (adjusted odds ratio, 2.7; 95% confidence interval, 1.3-5.9), and was particularly strong among subjects below age 55 (adjusted odds ratio, 5.1; 95% confidence interval, 1.6-16.1), Conclusions: These results suggest that familial aggregation of stomach cancer may be explained at least partly by familial clustering of H. pylori infection.