Techno-economic analysis of processes for Aspergillus carbonarius polygalacturonase production
Techno-economic analysis of processes for Aspergillus carbonarius polygalacturonase production
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DOI：
10.1016/j.jbiosc.2011.12.021
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发表时间：
2012-05-01
影响因子：
2.8
通讯作者：
Subramanian, Rangaswamy
中科院分区：
文献类型：
--
作者：
Nakkeeran, Ekambaram;Gowthaman, Marichetti Kuppuswamy;Subramanian, Rangaswamy
对碳曲霉生产聚半乳糖醛酸酶的浸没发酵（SmF）和固态发酵（SSF）工艺进行了技术经济分析，以确定合适的工艺选择。下游工艺包括集成膜工艺（IMP）和海藻酸盐亲和沉淀（AAP）。对于30 kL /年纯化聚半乳糖醛酸酶浓缩物的生产规模，SmF工艺的上游总成本比SSF工艺低14%。IMP的下游加工成本比AAP低47%。SmF-IMP工艺所需的总资本投资比SmF-AAP和SSF-AAP工艺低15-24%。在SmF-IMP工艺中，相应的单一产品成本也降低了24-36%。因此，从经济角度来看，SmF-IMP过程证明是非常有吸引力的。(C) 2012，生物技术学会，日本。版权所有。
A techno-economic analysis of submerged (SmF) and solid state fermentation (SSF) processes for Aspergillus carbonarius polygalacturonase production was performed to make an appropriate process selection. The downstream processing involved integrated membrane process (IMP) and alginate affinity precipitation (AAP). For a production scale of 30 kL purified polygalacturonase concentrate per year, the total upstream cost of SmF was 14% lower than the SSF process. Downstream processing cost by IMP was 47% lower than AAP. The SmF-IMP process required a total capital investment that was 15-24% lower than the SmF-AAP and SSF-AAP processes. The corresponding unitary product cost was also lower by 24-36% in SmF-IMP process. Thus the SmF-IMP process proved to be very attractive from an economic point of view. (C) 2012, The Society for Biotechnology, Japan. All rights reserved.