Stereoselective synthesis of 3-substituted phtalides via asymmetric transfer hydrogenation using well-defined ruthenium catalysts under neutral conditions
Stereoselective synthesis of 3-substituted phtalides via asymmetric transfer hydrogenation using well-defined ruthenium catalysts under neutral conditions
复制标题
DOI：
10.1016/s0040-4039(01)00076-4
复制
发表时间：
2001-03-04
影响因子：
1.8
通讯作者：
Carpentier, JF
中科院分区：
文献类型：
--
作者：
Everaere, K;Scheffler, JL;Carpentier, JF
2-酰基苯甲酸甲酯和3-乙酰基吡啶-2-甲酸2-丙酯在2-丙醇中，在不存在碱的情况下，使用预先合成的Ru-(β-氨基醇)或Ru-(TsDPEN)真实催化剂进行不对称转移氢化，以高收率和92-97% ee提供3-烷基邻苯二甲酸酯。然而，该方法对于制备光学活性 3-苯邻苯二甲酰内酯来说效率不高。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
The asymmetric transfer hydrogenation of methyl 2-acylbenzoates and 2-propyl 3-acetylpyridine- 2-carboxylate in 2-propanol, in the absence of base, with presynthesized Ru-{beta -amino alcohol) or Ru-{TsDPEN) true catalysts provides 3-alkylphtalides in high yields and 92-97% ee. The procedure is, however, not as efficient for the preparation of optically active 3-phenylphtalide. (C) 2001 Elsevier Science Ltd. All rights reserved.